Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery
The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the r...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/4565260 |
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| author | Yiming Huang Ping Yang |
| author_facet | Yiming Huang Ping Yang |
| author_sort | Yiming Huang |
| collection | DOAJ |
| description | The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared. By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved. The mechanical properties, permeability, and degradation rate of cross-linked and non-cross-linked hyaluronic acid composite nano-needles were studied in detail. Experimental results show that the higher the content of CHA, the slower the degradation rate of the microneedle, and the skin swelling of the HA_CHA (1 : 1) microneedle is the most lasting. With the increase of CHA content in microneedle matrix materials, the degree of epidermal expansion decreased. The preparation of cross-linked and non-cross-linked hyaluronic acid microneedles has the potential to be effectively used as dermal fillers in cosmetics or antiaging treatments. |
| format | Article |
| id | doaj-art-193d73cd84f046dc84b2e73302ad0d65 |
| institution | Kabale University |
| issn | 1687-8779 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-193d73cd84f046dc84b2e73302ad0d652025-02-03T01:07:36ZengWileyInternational Journal of Analytical Chemistry1687-87792022-01-01202210.1155/2022/4565260Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic SurgeryYiming Huang0Ping Yang1Gansu Provincial Maternity and Child-care HospitalGansu Provincial Maternity and Child-care HospitalThe common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared. By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved. The mechanical properties, permeability, and degradation rate of cross-linked and non-cross-linked hyaluronic acid composite nano-needles were studied in detail. Experimental results show that the higher the content of CHA, the slower the degradation rate of the microneedle, and the skin swelling of the HA_CHA (1 : 1) microneedle is the most lasting. With the increase of CHA content in microneedle matrix materials, the degree of epidermal expansion decreased. The preparation of cross-linked and non-cross-linked hyaluronic acid microneedles has the potential to be effectively used as dermal fillers in cosmetics or antiaging treatments.http://dx.doi.org/10.1155/2022/4565260 |
| spellingShingle | Yiming Huang Ping Yang Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery International Journal of Analytical Chemistry |
| title | Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery |
| title_full | Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery |
| title_fullStr | Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery |
| title_full_unstemmed | Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery |
| title_short | Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery |
| title_sort | application of cross linked and non cross linked hyaluronic acid nano needles in cosmetic surgery |
| url | http://dx.doi.org/10.1155/2022/4565260 |
| work_keys_str_mv | AT yiminghuang applicationofcrosslinkedandnoncrosslinkedhyaluronicacidnanoneedlesincosmeticsurgery AT pingyang applicationofcrosslinkedandnoncrosslinkedhyaluronicacidnanoneedlesincosmeticsurgery |