Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery
The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the r...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/4565260 |
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| Summary: | The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared. By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved. The mechanical properties, permeability, and degradation rate of cross-linked and non-cross-linked hyaluronic acid composite nano-needles were studied in detail. Experimental results show that the higher the content of CHA, the slower the degradation rate of the microneedle, and the skin swelling of the HA_CHA (1 : 1) microneedle is the most lasting. With the increase of CHA content in microneedle matrix materials, the degree of epidermal expansion decreased. The preparation of cross-linked and non-cross-linked hyaluronic acid microneedles has the potential to be effectively used as dermal fillers in cosmetics or antiaging treatments. |
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| ISSN: | 1687-8779 |