Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data
Background. In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance). Many patients with impaired glucose tolerance and undiagnosed diabetes do not know that their glucose metabolism system has been in...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/9949579 |
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| author | Rongpeng Gong Yuanyuan Liu Gang Luo Wenjing Liu Ziqi Jin Zixin Xu Zheng Li Lixin Yang Xiaoxing Wei |
| author_facet | Rongpeng Gong Yuanyuan Liu Gang Luo Wenjing Liu Ziqi Jin Zixin Xu Zheng Li Lixin Yang Xiaoxing Wei |
| author_sort | Rongpeng Gong |
| collection | DOAJ |
| description | Background. In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance). Many patients with impaired glucose tolerance and undiagnosed diabetes do not know that their glucose metabolism system has been in a state of disorder. Every year, about 5% to 10% of prediabetics develop diabetes. One of the important achieving factors may be the increase in blood lipids. However, it is not clear whether the triglyceride/high-density lipoprotein ratio is associated with impaired glucose tolerance and diabetes in the Chinese population. Therefore, we investigated the relationship between triglyceride/high-density lipoprotein and impaired glucose tolerance and diabetes in the Chinese population. Methods. We conducted a retrospective cohort study using data from the health screening program. The study included 116,855 participants from 32 locations in China, all of whom were adults over 20. Participants measured fasting blood glucose levels at each visit and collected information about their diabetes history. Impaired glucose tolerance was diagnosed as fasting blood glucose ≥6.00 mmol and self-reported diabetes mellitus. The patient was measured on the date of diagnosis or on his last visit (whichever comes first). Results. The results showed that, after adjusting the potential confounding factors, the ratio of TG/HDL was positively correlated with the occurrence of prediabetes and diabetes, and there was a saturation effect. The inflection points were 1.04 and 1.33, respectively. The effect value and 95% confidence interval before and after the inflection point of impaired glucose tolerance patients were 1.57 and (1.42, 1.73) and 1.03 and (1.01, 1.05), respectively. The effect value and 95% confidence interval before and after the inflection point in patients with diabetes were 2.07 and (1.80, 2.39) and 1.08 and (1.04, 1.12). |
| format | Article |
| id | doaj-art-193985b8981f45baa6e0df9901b2c155 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-193985b8981f45baa6e0df9901b2c1552025-02-03T05:48:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/99495799949579Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open DataRongpeng Gong0Yuanyuan Liu1Gang Luo2Wenjing Liu3Ziqi Jin4Zixin Xu5Zheng Li6Lixin Yang7Xiaoxing Wei8Medical College of Qinghai University, Xining, Qinghai 810016, ChinaMedical College of Qinghai University, Xining, Qinghai 810016, ChinaCollege of Eco-environmental Engineering, Qinghai University, Xining, Qinghai 810016, ChinaMedical College of Qinghai University, Xining, Qinghai 810016, ChinaCenter for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, ChinaShaanxi University of Chinese Medicine, Xi’an, Shaanxi 712046, ChinaEndocrinology Department, Qinghai Provincial People’s Hospital, Xining, Qinghai 810007, ChinaEndocrinology Department, Qinghai Provincial People’s Hospital, Xining, Qinghai 810007, ChinaMedical College of Qinghai University, Xining, Qinghai 810016, ChinaBackground. In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance). Many patients with impaired glucose tolerance and undiagnosed diabetes do not know that their glucose metabolism system has been in a state of disorder. Every year, about 5% to 10% of prediabetics develop diabetes. One of the important achieving factors may be the increase in blood lipids. However, it is not clear whether the triglyceride/high-density lipoprotein ratio is associated with impaired glucose tolerance and diabetes in the Chinese population. Therefore, we investigated the relationship between triglyceride/high-density lipoprotein and impaired glucose tolerance and diabetes in the Chinese population. Methods. We conducted a retrospective cohort study using data from the health screening program. The study included 116,855 participants from 32 locations in China, all of whom were adults over 20. Participants measured fasting blood glucose levels at each visit and collected information about their diabetes history. Impaired glucose tolerance was diagnosed as fasting blood glucose ≥6.00 mmol and self-reported diabetes mellitus. The patient was measured on the date of diagnosis or on his last visit (whichever comes first). Results. The results showed that, after adjusting the potential confounding factors, the ratio of TG/HDL was positively correlated with the occurrence of prediabetes and diabetes, and there was a saturation effect. The inflection points were 1.04 and 1.33, respectively. The effect value and 95% confidence interval before and after the inflection point of impaired glucose tolerance patients were 1.57 and (1.42, 1.73) and 1.03 and (1.01, 1.05), respectively. The effect value and 95% confidence interval before and after the inflection point in patients with diabetes were 2.07 and (1.80, 2.39) and 1.08 and (1.04, 1.12).http://dx.doi.org/10.1155/2021/9949579 |
| spellingShingle | Rongpeng Gong Yuanyuan Liu Gang Luo Wenjing Liu Ziqi Jin Zixin Xu Zheng Li Lixin Yang Xiaoxing Wei Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data International Journal of Endocrinology |
| title | Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data |
| title_full | Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data |
| title_fullStr | Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data |
| title_full_unstemmed | Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data |
| title_short | Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data |
| title_sort | associations of tg hdl ratio with the risk of prediabetes and diabetes in chinese adults a chinese population cohort study based on open data |
| url | http://dx.doi.org/10.1155/2021/9949579 |
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