Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour
Understanding the factors that influence the pH responsive behaviour of biocompatible cross-linked hydrogel networks is essential when aiming to synthesise a mechanically stable and yet stimuli responsive material suitable for various applications including drug delivery and tissue engineering. In t...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2015/621289 |
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| _version_ | 1832556938949296128 |
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| author | Chinyelumndu Jennifer Nwosu Glenn Adam Hurst Katarina Novakovic |
| author_facet | Chinyelumndu Jennifer Nwosu Glenn Adam Hurst Katarina Novakovic |
| author_sort | Chinyelumndu Jennifer Nwosu |
| collection | DOAJ |
| description | Understanding the factors that influence the pH responsive behaviour of biocompatible cross-linked hydrogel networks is essential when aiming to synthesise a mechanically stable and yet stimuli responsive material suitable for various applications including drug delivery and tissue engineering. In this study the behaviour of intelligent chitosan-polyvinylpyrrolidone-genipin cross-linked hydrogels is examined as a function of their composition and postsynthesis treatment. Hydrogels are synthesised with varying amounts of each component (chitosan, polyvinylpyrrolidone, and genipin) and their response in a pH 2 buffer is measured optically. The influence of postsynthesis treatment on stability and smart characteristics is assessed using selected hydrogel samples synthesised at 30, 40, and 50°C. After synthesis, samples are exposed to either continuous freezing or three freeze-thaw cycles resulting in increased mechanical stability for all samples. Further morphological and mechanical characterisations have aided the understanding of how postsynthesis continual freezing or freeze-thaw manipulation affects network attributes. |
| format | Article |
| id | doaj-art-193531b825224fc9b7ee2b9a92b7b326 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-193531b825224fc9b7ee2b9a92b7b3262025-02-03T05:44:03ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422015-01-01201510.1155/2015/621289621289Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive BehaviourChinyelumndu Jennifer Nwosu0Glenn Adam Hurst1Katarina Novakovic2School of Chemical Engineering and Advanced Materials, Newcastle University, Merz Court, Newcastle NE1 7RU, UKSchool of Chemical Engineering and Advanced Materials, Newcastle University, Merz Court, Newcastle NE1 7RU, UKSchool of Chemical Engineering and Advanced Materials, Newcastle University, Merz Court, Newcastle NE1 7RU, UKUnderstanding the factors that influence the pH responsive behaviour of biocompatible cross-linked hydrogel networks is essential when aiming to synthesise a mechanically stable and yet stimuli responsive material suitable for various applications including drug delivery and tissue engineering. In this study the behaviour of intelligent chitosan-polyvinylpyrrolidone-genipin cross-linked hydrogels is examined as a function of their composition and postsynthesis treatment. Hydrogels are synthesised with varying amounts of each component (chitosan, polyvinylpyrrolidone, and genipin) and their response in a pH 2 buffer is measured optically. The influence of postsynthesis treatment on stability and smart characteristics is assessed using selected hydrogel samples synthesised at 30, 40, and 50°C. After synthesis, samples are exposed to either continuous freezing or three freeze-thaw cycles resulting in increased mechanical stability for all samples. Further morphological and mechanical characterisations have aided the understanding of how postsynthesis continual freezing or freeze-thaw manipulation affects network attributes.http://dx.doi.org/10.1155/2015/621289 |
| spellingShingle | Chinyelumndu Jennifer Nwosu Glenn Adam Hurst Katarina Novakovic Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour Advances in Materials Science and Engineering |
| title | Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour |
| title_full | Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour |
| title_fullStr | Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour |
| title_full_unstemmed | Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour |
| title_short | Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour |
| title_sort | genipin cross linked chitosan polyvinylpyrrolidone hydrogels influence of composition and postsynthesis treatment on ph responsive behaviour |
| url | http://dx.doi.org/10.1155/2015/621289 |
| work_keys_str_mv | AT chinyelumndujennifernwosu genipincrosslinkedchitosanpolyvinylpyrrolidonehydrogelsinfluenceofcompositionandpostsynthesistreatmentonphresponsivebehaviour AT glennadamhurst genipincrosslinkedchitosanpolyvinylpyrrolidonehydrogelsinfluenceofcompositionandpostsynthesistreatmentonphresponsivebehaviour AT katarinanovakovic genipincrosslinkedchitosanpolyvinylpyrrolidonehydrogelsinfluenceofcompositionandpostsynthesistreatmentonphresponsivebehaviour |