Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis
Introduction. Infectious mononucleosis (IM), caused by the Epstein–Barr virus (EBV), typically presents with fever, tonsillopharyngitis, and lymphadenopathy while rare, renal, and hematological complications such as gross hematuria and hemolytic anemia can occur, particularly in children. Case Prese...
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Wiley
2024-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2024/5236969 |
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| author | Chinmayi Sharma Navneet Venugopal Shivaiah Balachandra |
| author_facet | Chinmayi Sharma Navneet Venugopal Shivaiah Balachandra |
| author_sort | Chinmayi Sharma |
| collection | DOAJ |
| description | Introduction. Infectious mononucleosis (IM), caused by the Epstein–Barr virus (EBV), typically presents with fever, tonsillopharyngitis, and lymphadenopathy while rare, renal, and hematological complications such as gross hematuria and hemolytic anemia can occur, particularly in children. Case Presentation. We describe a 15-year-old male with infectious mononucleosis presenting with abdominal pain, sore throat, and red-colored urine for three days. Laboratory findings revealed leukocytosis, elevated liver enzymes, and hemoglobinuria. Serological testing confirmed EBV infection. Despite intravascular hemolysis, the patient’s anemia was mild, and he responded well to supportive care. Discussion. Gross hematuria and hemolytic anemia are uncommon in IM, with limited reports. Proposed mechanisms include viral-induced renal injury and autoimmune hemolysis. Differential diagnosis should consider other causes of hematuria, which can be differentiated through urine microscopy and serological tests. IM should be considered in patients with pharyngitis and hematuria, especially when other causes are excluded. |
| format | Article |
| id | doaj-art-192ebd3e10c249e0bcb6f4851bc607ff |
| institution | Kabale University |
| issn | 2090-6811 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-192ebd3e10c249e0bcb6f4851bc607ff2025-02-03T00:19:48ZengWileyCase Reports in Pediatrics2090-68112024-01-01202410.1155/2024/5236969Gross Hematuria and Hemolytic Anemia in Infectious MononucleosisChinmayi Sharma0Navneet Venugopal1Shivaiah Balachandra2AJ Institute of Medical Sciences and Research CenterDepartment of PediatricsDivision of Pediatric NephrologyIntroduction. Infectious mononucleosis (IM), caused by the Epstein–Barr virus (EBV), typically presents with fever, tonsillopharyngitis, and lymphadenopathy while rare, renal, and hematological complications such as gross hematuria and hemolytic anemia can occur, particularly in children. Case Presentation. We describe a 15-year-old male with infectious mononucleosis presenting with abdominal pain, sore throat, and red-colored urine for three days. Laboratory findings revealed leukocytosis, elevated liver enzymes, and hemoglobinuria. Serological testing confirmed EBV infection. Despite intravascular hemolysis, the patient’s anemia was mild, and he responded well to supportive care. Discussion. Gross hematuria and hemolytic anemia are uncommon in IM, with limited reports. Proposed mechanisms include viral-induced renal injury and autoimmune hemolysis. Differential diagnosis should consider other causes of hematuria, which can be differentiated through urine microscopy and serological tests. IM should be considered in patients with pharyngitis and hematuria, especially when other causes are excluded.http://dx.doi.org/10.1155/2024/5236969 |
| spellingShingle | Chinmayi Sharma Navneet Venugopal Shivaiah Balachandra Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis Case Reports in Pediatrics |
| title | Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis |
| title_full | Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis |
| title_fullStr | Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis |
| title_full_unstemmed | Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis |
| title_short | Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis |
| title_sort | gross hematuria and hemolytic anemia in infectious mononucleosis |
| url | http://dx.doi.org/10.1155/2024/5236969 |
| work_keys_str_mv | AT chinmayisharma grosshematuriaandhemolyticanemiaininfectiousmononucleosis AT navneetvenugopal grosshematuriaandhemolyticanemiaininfectiousmononucleosis AT shivaiahbalachandra grosshematuriaandhemolyticanemiaininfectiousmononucleosis |