Maternal Thyroid Dysfunction and Neonatal Thyroid Problems
Aim. To investigate obstetric features of pregnant women with thyroid disorders and thyroid function tests of their newborn infants. Methods. Women with hypothyroidism and having anti-thyroglobulin (ATG) and anti-thyroid peroxidase (anti-TPO) antibodies were assigned as group I, women with hypothyro...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/987843 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562242062647296 |
|---|---|
| author | Hulya Ozdemir Ipek Akman Senay Coskun Utku Demirel Serap Turan Abdullah Bereket Hulya Bilgen Eren Ozek |
| author_facet | Hulya Ozdemir Ipek Akman Senay Coskun Utku Demirel Serap Turan Abdullah Bereket Hulya Bilgen Eren Ozek |
| author_sort | Hulya Ozdemir |
| collection | DOAJ |
| description | Aim. To investigate obstetric features of pregnant women with thyroid disorders and thyroid function tests of their newborn infants. Methods. Women with hypothyroidism and having anti-thyroglobulin (ATG) and anti-thyroid peroxidase (anti-TPO) antibodies were assigned as group I, women with hypothyroidism who did not have autoantibodies were assigned as group II, and women without thyroid problems were assigned as group III. Results. Pregnant women with autoimmune hypothyroidism (group I) had more preterm delivery and their babies needed more frequent neonatal intensive care unit (NICU) admission. In group I, one infant was diagnosed with compensated hypothyroidism and one infant had transient hyperthyrotropinemia. Five infants (23.8%) in group II had thyroid-stimulating hormone (TSH) levels >20 mIU/mL. Only two of them had TSH level >7 mIU/L at the 3rd postnatal week, and all had normal free T4 (FT4). Median maternal TSH level of these five infants with TSH >20 mIU/mL was 6.6 mIU/mL. In group III, six infants (6.5%) had TSH levels above >20 mIU/mL at the 1st postnatal week. Conclusion. Infants of mothers with thyroid problems are more likely to have elevated TSH and higher recall rate on neonatal thyroid screening. Women with thyroid disorders and their newborn infants should be followed closely for both obstetrical problems and for thyroid dysfunction. |
| format | Article |
| id | doaj-art-192295c3e5ac451abb500a5834de5408 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-192295c3e5ac451abb500a5834de54082025-02-03T01:23:06ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/987843987843Maternal Thyroid Dysfunction and Neonatal Thyroid ProblemsHulya Ozdemir0Ipek Akman1Senay Coskun2Utku Demirel3Serap Turan4Abdullah Bereket5Hulya Bilgen6Eren Ozek7Department of Pediatrics, Division of Neonatology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Pediatrics, Division of Neonatology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Pediatrics, Division of Neonatology, Marmara University School of Medicine, Istanbul, TurkeyYakacik Maternity and Children State Hospital, Istanbul, TurkeyDepartment of Pediatrics, Division of Endocrinology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Pediatrics, Division of Endocrinology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Pediatrics, Division of Neonatology, Marmara University School of Medicine, Istanbul, TurkeyDepartment of Pediatrics, Division of Neonatology, Marmara University School of Medicine, Istanbul, TurkeyAim. To investigate obstetric features of pregnant women with thyroid disorders and thyroid function tests of their newborn infants. Methods. Women with hypothyroidism and having anti-thyroglobulin (ATG) and anti-thyroid peroxidase (anti-TPO) antibodies were assigned as group I, women with hypothyroidism who did not have autoantibodies were assigned as group II, and women without thyroid problems were assigned as group III. Results. Pregnant women with autoimmune hypothyroidism (group I) had more preterm delivery and their babies needed more frequent neonatal intensive care unit (NICU) admission. In group I, one infant was diagnosed with compensated hypothyroidism and one infant had transient hyperthyrotropinemia. Five infants (23.8%) in group II had thyroid-stimulating hormone (TSH) levels >20 mIU/mL. Only two of them had TSH level >7 mIU/L at the 3rd postnatal week, and all had normal free T4 (FT4). Median maternal TSH level of these five infants with TSH >20 mIU/mL was 6.6 mIU/mL. In group III, six infants (6.5%) had TSH levels above >20 mIU/mL at the 1st postnatal week. Conclusion. Infants of mothers with thyroid problems are more likely to have elevated TSH and higher recall rate on neonatal thyroid screening. Women with thyroid disorders and their newborn infants should be followed closely for both obstetrical problems and for thyroid dysfunction.http://dx.doi.org/10.1155/2013/987843 |
| spellingShingle | Hulya Ozdemir Ipek Akman Senay Coskun Utku Demirel Serap Turan Abdullah Bereket Hulya Bilgen Eren Ozek Maternal Thyroid Dysfunction and Neonatal Thyroid Problems International Journal of Endocrinology |
| title | Maternal Thyroid Dysfunction and Neonatal Thyroid Problems |
| title_full | Maternal Thyroid Dysfunction and Neonatal Thyroid Problems |
| title_fullStr | Maternal Thyroid Dysfunction and Neonatal Thyroid Problems |
| title_full_unstemmed | Maternal Thyroid Dysfunction and Neonatal Thyroid Problems |
| title_short | Maternal Thyroid Dysfunction and Neonatal Thyroid Problems |
| title_sort | maternal thyroid dysfunction and neonatal thyroid problems |
| url | http://dx.doi.org/10.1155/2013/987843 |
| work_keys_str_mv | AT hulyaozdemir maternalthyroiddysfunctionandneonatalthyroidproblems AT ipekakman maternalthyroiddysfunctionandneonatalthyroidproblems AT senaycoskun maternalthyroiddysfunctionandneonatalthyroidproblems AT utkudemirel maternalthyroiddysfunctionandneonatalthyroidproblems AT serapturan maternalthyroiddysfunctionandneonatalthyroidproblems AT abdullahbereket maternalthyroiddysfunctionandneonatalthyroidproblems AT hulyabilgen maternalthyroiddysfunctionandneonatalthyroidproblems AT erenozek maternalthyroiddysfunctionandneonatalthyroidproblems |