BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Alzheimer’s disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. Studies over the past few decades suggest that Aβ is produced in an activity-dependent manner and has physiological relevan...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/128631 |
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| author | Emily Petrus Hey-Kyoung Lee |
| author_facet | Emily Petrus Hey-Kyoung Lee |
| author_sort | Emily Petrus |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. Studies over the past few decades suggest that Aβ is produced in an activity-dependent manner and has physiological relevance to normal brain functions. Similarly, physiological functions for β- and γ-secretases, the two key enzymes that produce Aβ by sequentially processing the amyloid precursor protein (APP), have been discovered over recent years. In particular, activity-dependent production of Aβ has been suggested to play a role in homeostatic regulation of excitatory synaptic function. There is accumulating evidence that activity-dependent immediate early gene Arc is an activity “sensor,” which acts upstream of Aβ production and triggers AMPA receptor endocytosis to homeostatically downregulate the strength of excitatory synaptic transmission. We previously reported that Arc is critical for sensory experience-dependent homeostatic reduction of excitatory synaptic transmission in the superficial layers of visual cortex. Here we demonstrate that mice lacking the major neuronal β-secretase, BACE1, exhibit a similar phenotype: stronger basal excitatory synaptic transmission and failure to adapt to changes in visual experience. Our results indicate that BACE1 plays an essential role in sensory experience-dependent homeostatic synaptic plasticity in the neocortex. |
| format | Article |
| id | doaj-art-190f9ea7f0444a639ed83f52d69c0ed6 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-190f9ea7f0444a639ed83f52d69c0ed62025-02-03T01:22:31ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/128631128631BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual CortexEmily Petrus0Hey-Kyoung Lee1Zanvyl-Krieger Mind/Brain Institute, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall 348, Baltimore, MD 21218, USAZanvyl-Krieger Mind/Brain Institute, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall 348, Baltimore, MD 21218, USAAlzheimer’s disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. Studies over the past few decades suggest that Aβ is produced in an activity-dependent manner and has physiological relevance to normal brain functions. Similarly, physiological functions for β- and γ-secretases, the two key enzymes that produce Aβ by sequentially processing the amyloid precursor protein (APP), have been discovered over recent years. In particular, activity-dependent production of Aβ has been suggested to play a role in homeostatic regulation of excitatory synaptic function. There is accumulating evidence that activity-dependent immediate early gene Arc is an activity “sensor,” which acts upstream of Aβ production and triggers AMPA receptor endocytosis to homeostatically downregulate the strength of excitatory synaptic transmission. We previously reported that Arc is critical for sensory experience-dependent homeostatic reduction of excitatory synaptic transmission in the superficial layers of visual cortex. Here we demonstrate that mice lacking the major neuronal β-secretase, BACE1, exhibit a similar phenotype: stronger basal excitatory synaptic transmission and failure to adapt to changes in visual experience. Our results indicate that BACE1 plays an essential role in sensory experience-dependent homeostatic synaptic plasticity in the neocortex.http://dx.doi.org/10.1155/2014/128631 |
| spellingShingle | Emily Petrus Hey-Kyoung Lee BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex Neural Plasticity |
| title | BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex |
| title_full | BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex |
| title_fullStr | BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex |
| title_full_unstemmed | BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex |
| title_short | BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex |
| title_sort | bace1 is necessary for experience dependent homeostatic synaptic plasticity in visual cortex |
| url | http://dx.doi.org/10.1155/2014/128631 |
| work_keys_str_mv | AT emilypetrus bace1isnecessaryforexperiencedependenthomeostaticsynapticplasticityinvisualcortex AT heykyounglee bace1isnecessaryforexperiencedependenthomeostaticsynapticplasticityinvisualcortex |