The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor
Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/820853 |
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| author | Kadir Kirboga Ayse V. Ozec Mustafa Kosker Ayhan Dursun Mustafa I. Toker Huseyin Aydin Haydar Erdogan Aysen Topalkara Mustafa K. Arici |
| author_facet | Kadir Kirboga Ayse V. Ozec Mustafa Kosker Ayhan Dursun Mustafa I. Toker Huseyin Aydin Haydar Erdogan Aysen Topalkara Mustafa K. Arici |
| author_sort | Kadir Kirboga |
| collection | DOAJ |
| description | Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P=0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P=0.004). Mean TOS levels in the serum were 2.93 ± 0.19 in the DRP group and 2.61 ± 0.26 in the control group (P=0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development. |
| format | Article |
| id | doaj-art-18ecf31ed6744fe1b74e8297f7895d1a |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-18ecf31ed6744fe1b74e8297f7895d1a2025-02-03T01:33:05ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/820853820853The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous HumorKadir Kirboga0Ayse V. Ozec1Mustafa Kosker2Ayhan Dursun3Mustafa I. Toker4Huseyin Aydin5Haydar Erdogan6Aysen Topalkara7Mustafa K. Arici8Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Ophthalmology, Ulus State Hospital, Ankara, TurkeyDepartment of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Biochemistry, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyDepartment of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, TurkeyPurpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P=0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P=0.004). Mean TOS levels in the serum were 2.93 ± 0.19 in the DRP group and 2.61 ± 0.26 in the control group (P=0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.http://dx.doi.org/10.1155/2014/820853 |
| spellingShingle | Kadir Kirboga Ayse V. Ozec Mustafa Kosker Ayhan Dursun Mustafa I. Toker Huseyin Aydin Haydar Erdogan Aysen Topalkara Mustafa K. Arici The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor Journal of Ophthalmology |
| title | The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor |
| title_full | The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor |
| title_fullStr | The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor |
| title_full_unstemmed | The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor |
| title_short | The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor |
| title_sort | association between diabetic retinopathy and levels of ischemia modified albumin total thiol total antioxidant capacity and total oxidative stress in serum and aqueous humor |
| url | http://dx.doi.org/10.1155/2014/820853 |
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