Biomarkers of inflammation and colorectal cancer risk
Globally, colorectal malignancy ranks among the most prevalent forms of cancer and stands as the third principal cause of cancer-associated mortality. Recent studies indicate that inflammatory processes play a significant role in the initiation and advancement of various malignancies, colorectal can...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514009/full |
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| author | Yuting Li Yuting Li Yuting Li Yuexin Luo Yue Ran Furong Lu You Qin |
| author_facet | Yuting Li Yuting Li Yuting Li Yuexin Luo Yue Ran Furong Lu You Qin |
| author_sort | Yuting Li |
| collection | DOAJ |
| description | Globally, colorectal malignancy ranks among the most prevalent forms of cancer and stands as the third principal cause of cancer-associated mortality. Recent studies indicate that inflammatory processes play a significant role in the initiation and advancement of various malignancies, colorectal cancer included. It explores inflammatory biomarkers, with C-reactive protein (CRP) being a key focus. While CRP’s elevation during inflammation is linked to tumorigenesis, studies on its association with CRC risk are inconsistent, showing gender and methodological differences. Interleukin-6 (IL-6), TNF - α, and their receptors also play roles in CRC development, yet research findings vary. Adiponectin and leptin, secreted by adipocytes, have complex associations with CRC, with gender disparities noted. In terms of screening, non-invasive methods like fecal occult blood tests (FOBTs) are widely used, and combining biomarkers with iFOBT shows potential. Multi-omics techniques, including genomics and microbiomics, offer new avenues for CRC diagnosis. Overall, while evidence highlights the significance of inflammatory biomarkers in CRC risk prediction, larger prospective studies are urgently needed to clarify their roles due to existing inconsistencies and methodological limitations. |
| format | Article |
| id | doaj-art-18e3971384004e4c8d831ea5b4d78683 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-18e3971384004e4c8d831ea5b4d786832025-02-06T05:21:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15140091514009Biomarkers of inflammation and colorectal cancer riskYuting Li0Yuting Li1Yuting Li2Yuexin Luo3Yue Ran4Furong Lu5You Qin6Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Precision Radiation Oncology, Wuhan, ChinaFirst Clinic School, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSecond Clinic School, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaGlobally, colorectal malignancy ranks among the most prevalent forms of cancer and stands as the third principal cause of cancer-associated mortality. Recent studies indicate that inflammatory processes play a significant role in the initiation and advancement of various malignancies, colorectal cancer included. It explores inflammatory biomarkers, with C-reactive protein (CRP) being a key focus. While CRP’s elevation during inflammation is linked to tumorigenesis, studies on its association with CRC risk are inconsistent, showing gender and methodological differences. Interleukin-6 (IL-6), TNF - α, and their receptors also play roles in CRC development, yet research findings vary. Adiponectin and leptin, secreted by adipocytes, have complex associations with CRC, with gender disparities noted. In terms of screening, non-invasive methods like fecal occult blood tests (FOBTs) are widely used, and combining biomarkers with iFOBT shows potential. Multi-omics techniques, including genomics and microbiomics, offer new avenues for CRC diagnosis. Overall, while evidence highlights the significance of inflammatory biomarkers in CRC risk prediction, larger prospective studies are urgently needed to clarify their roles due to existing inconsistencies and methodological limitations.https://www.frontiersin.org/articles/10.3389/fonc.2025.1514009/fullcolorectal cancerinflammationC-reactive protein (CRP)interleukin (IL)-6tumor necrosis factor-alpha (TNF-α) |
| spellingShingle | Yuting Li Yuting Li Yuting Li Yuexin Luo Yue Ran Furong Lu You Qin Biomarkers of inflammation and colorectal cancer risk Frontiers in Oncology colorectal cancer inflammation C-reactive protein (CRP) interleukin (IL)-6 tumor necrosis factor-alpha (TNF-α) |
| title | Biomarkers of inflammation and colorectal cancer risk |
| title_full | Biomarkers of inflammation and colorectal cancer risk |
| title_fullStr | Biomarkers of inflammation and colorectal cancer risk |
| title_full_unstemmed | Biomarkers of inflammation and colorectal cancer risk |
| title_short | Biomarkers of inflammation and colorectal cancer risk |
| title_sort | biomarkers of inflammation and colorectal cancer risk |
| topic | colorectal cancer inflammation C-reactive protein (CRP) interleukin (IL)-6 tumor necrosis factor-alpha (TNF-α) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514009/full |
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