Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction
The advent of genomic analyses has revolutionized the study of human health. Infectious disease research in particular has experienced an explosion of bacterial genomic, transcriptomic, and proteomic data complementing the phenotypic methods employed in traditional bacteriology. Together, these tech...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2015/386905 |
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| _version_ | 1832551930518306816 |
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| author | Kathryn P. Haley Jennifer A. Gaddy |
| author_facet | Kathryn P. Haley Jennifer A. Gaddy |
| author_sort | Kathryn P. Haley |
| collection | DOAJ |
| description | The advent of genomic analyses has revolutionized the study of human health. Infectious disease research in particular has experienced an explosion of bacterial genomic, transcriptomic, and proteomic data complementing the phenotypic methods employed in traditional bacteriology. Together, these techniques have revealed novel virulence determinants in numerous pathogens and have provided information for potential chemotherapeutics. The bacterial pathogen, Helicobacter pylori, has been recognized as a class 1 carcinogen and contributes to chronic inflammation within the gastric niche. Genomic analyses have uncovered remarkable coevolution between the human host and H. pylori. Perturbation of this coevolution results in dysregulation of the host-pathogen interaction, leading to oncogenic effects. This review discusses the relationship of H. pylori with the human host and environment and the contribution of each of these factors to disease progression, with an emphasis on features that have been illuminated by genomic tools. |
| format | Article |
| id | doaj-art-18dfdddabbfa44529443b39408f91473 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-18dfdddabbfa44529443b39408f914732025-02-03T06:00:04ZengWileyInternational Journal of Genomics2314-436X2314-43782015-01-01201510.1155/2015/386905386905Helicobacter pylori: Genomic Insight into the Host-Pathogen InteractionKathryn P. Haley0Jennifer A. Gaddy1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USAThe advent of genomic analyses has revolutionized the study of human health. Infectious disease research in particular has experienced an explosion of bacterial genomic, transcriptomic, and proteomic data complementing the phenotypic methods employed in traditional bacteriology. Together, these techniques have revealed novel virulence determinants in numerous pathogens and have provided information for potential chemotherapeutics. The bacterial pathogen, Helicobacter pylori, has been recognized as a class 1 carcinogen and contributes to chronic inflammation within the gastric niche. Genomic analyses have uncovered remarkable coevolution between the human host and H. pylori. Perturbation of this coevolution results in dysregulation of the host-pathogen interaction, leading to oncogenic effects. This review discusses the relationship of H. pylori with the human host and environment and the contribution of each of these factors to disease progression, with an emphasis on features that have been illuminated by genomic tools.http://dx.doi.org/10.1155/2015/386905 |
| spellingShingle | Kathryn P. Haley Jennifer A. Gaddy Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction International Journal of Genomics |
| title | Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction |
| title_full | Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction |
| title_fullStr | Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction |
| title_full_unstemmed | Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction |
| title_short | Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction |
| title_sort | helicobacter pylori genomic insight into the host pathogen interaction |
| url | http://dx.doi.org/10.1155/2015/386905 |
| work_keys_str_mv | AT kathrynphaley helicobacterpylorigenomicinsightintothehostpathogeninteraction AT jenniferagaddy helicobacterpylorigenomicinsightintothehostpathogeninteraction |