PEDF-Expressing mesenchymal stem cells restore ovarian function via Tim-3-Mediated immune modulation in primary ovarian failure

PEDF-Expressing mesenchymal stem cells restore ovarian function via Tim-3-Mediated immune modulation in primary ovarian failure

Abstract Background Primary ovarian failure (POF), characterized by premature ovarian dysfunction, remains a therapeutic challenge due to limited interventions addressing its immune dysregulation. Regulatory T cells (Tregs) and immune checkPOFnt pathways, such as Tim-3, are critical yet underexplore...

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Bibliographic Details
Main Authors: Seyida Yimamuyushan, Song Shi, Aikeremujiang Muheremu, Jinling Yi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Ovarian Research
Subjects:
Primary ovarian failure
Immune checkpofnt
Regulatory t cells
Gene-engineered stem cells
Ovarian regeneration
Online Access:https://doi.org/10.1186/s13048-025-01778-0
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