Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics
The diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/545403 |
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| author | P. Rashmi Gopal Krishna Rao Kshama Devi B. G. Shivananda G. R. Swetha G. A. Suneetha |
| author_facet | P. Rashmi Gopal Krishna Rao Kshama Devi B. G. Shivananda G. R. Swetha G. A. Suneetha |
| author_sort | P. Rashmi |
| collection | DOAJ |
| description | The diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity. A series of new aryl ether derivatives [4(a-h), 5] were prepared by Ullmann’s ether condensation. The structures of new compounds are supported by their IR, 1H NMR and Mass spectra. The new derivatives were evaluated for their antiinflammatory and analgesic activity. Among the tested, compound 3 has shown better antiinflammatory and analgesic activity. |
| format | Article |
| id | doaj-art-18a4c8bdaf604974a5701c1b633edb10 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-18a4c8bdaf604974a5701c1b633edb102025-02-03T01:21:59ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01831401140710.1155/2011/545403Novel Aryl Ether Derivatives as Antiinflammatory and AnalgesicsP. Rashmi0Gopal Krishna Rao1Kshama Devi2B. G. Shivananda3G. R. Swetha4G. A. Suneetha5Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, IndiaNargund College of Pharmacy, II Main Dattatreyanagar, Bangalore-560085, IndiaDepartment of Pharmacology , Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, IndiaDepartment of Pharmacology , Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, IndiaNargund College of Pharmacy, II Main Dattatreyanagar, Bangalore-560085, IndiaDepartment of Pharmacology , Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, IndiaThe diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity. A series of new aryl ether derivatives [4(a-h), 5] were prepared by Ullmann’s ether condensation. The structures of new compounds are supported by their IR, 1H NMR and Mass spectra. The new derivatives were evaluated for their antiinflammatory and analgesic activity. Among the tested, compound 3 has shown better antiinflammatory and analgesic activity.http://dx.doi.org/10.1155/2011/545403 |
| spellingShingle | P. Rashmi Gopal Krishna Rao Kshama Devi B. G. Shivananda G. R. Swetha G. A. Suneetha Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics E-Journal of Chemistry |
| title | Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics |
| title_full | Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics |
| title_fullStr | Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics |
| title_full_unstemmed | Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics |
| title_short | Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics |
| title_sort | novel aryl ether derivatives as antiinflammatory and analgesics |
| url | http://dx.doi.org/10.1155/2011/545403 |
| work_keys_str_mv | AT prashmi novelaryletherderivativesasantiinflammatoryandanalgesics AT gopalkrishnarao novelaryletherderivativesasantiinflammatoryandanalgesics AT kshamadevi novelaryletherderivativesasantiinflammatoryandanalgesics AT bgshivananda novelaryletherderivativesasantiinflammatoryandanalgesics AT grswetha novelaryletherderivativesasantiinflammatoryandanalgesics AT gasuneetha novelaryletherderivativesasantiinflammatoryandanalgesics |