Bipolar Disorder and Multiple Sclerosis: A Case Series
Background. The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. Observations. Al...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2014/536503 |
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| author | Youssef Sidhom Mouna Ben Djebara Yosr Hizem Istabrak Abdelkefi Imen Kacem Amina Gargouri Riadh Gouider |
| author_facet | Youssef Sidhom Mouna Ben Djebara Yosr Hizem Istabrak Abdelkefi Imen Kacem Amina Gargouri Riadh Gouider |
| author_sort | Youssef Sidhom |
| collection | DOAJ |
| description | Background. The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. Observations. All patients fulfilled the McDonald criteria for MS. Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS. A third patient was diagnosed with MS and developed deferred psychotic symptoms. Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms. All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment. Conclusions. MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits. |
| format | Article |
| id | doaj-art-189c66cd99714f97bf3c709fcf16319b |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-189c66cd99714f97bf3c709fcf16319b2025-02-03T06:45:18ZengWileyBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/536503536503Bipolar Disorder and Multiple Sclerosis: A Case SeriesYoussef Sidhom0Mouna Ben Djebara1Yosr Hizem2Istabrak Abdelkefi3Imen Kacem4Amina Gargouri5Riadh Gouider6Department of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaDepartment of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaDepartment of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaDepartment of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaDepartment of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaDepartment of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaDepartment of Neurology, Razi Hospital, Manouba, 2010 Tunis, TunisiaBackground. The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. Observations. All patients fulfilled the McDonald criteria for MS. Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS. A third patient was diagnosed with MS and developed deferred psychotic symptoms. Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms. All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment. Conclusions. MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.http://dx.doi.org/10.1155/2014/536503 |
| spellingShingle | Youssef Sidhom Mouna Ben Djebara Yosr Hizem Istabrak Abdelkefi Imen Kacem Amina Gargouri Riadh Gouider Bipolar Disorder and Multiple Sclerosis: A Case Series Behavioural Neurology |
| title | Bipolar Disorder and Multiple Sclerosis: A Case Series |
| title_full | Bipolar Disorder and Multiple Sclerosis: A Case Series |
| title_fullStr | Bipolar Disorder and Multiple Sclerosis: A Case Series |
| title_full_unstemmed | Bipolar Disorder and Multiple Sclerosis: A Case Series |
| title_short | Bipolar Disorder and Multiple Sclerosis: A Case Series |
| title_sort | bipolar disorder and multiple sclerosis a case series |
| url | http://dx.doi.org/10.1155/2014/536503 |
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