Pediatric Ovarian Growing Teratoma Syndrome
Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or fo...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2017/3074240 |
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| _version_ | 1832545695770345472 |
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| author | Rebecca M. Rentea Aaron Varghese Atif Ahmed Alexander Kats Michelle Manalang Tazim Dowlut-McElroy Richard J. Hendrickson |
| author_facet | Rebecca M. Rentea Aaron Varghese Atif Ahmed Alexander Kats Michelle Manalang Tazim Dowlut-McElroy Richard J. Hendrickson |
| author_sort | Rebecca M. Rentea |
| collection | DOAJ |
| description | Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation. Current treatment modality is surgical resection. We discuss a 12-year-old female who presented following resection of a pure ovarian immature teratoma (grade 3, FIGO stage IIIC). Following chemotherapy and resection of a pelvic/liver recurrence demonstrating mature teratoma, she underwent molecular genetics based chemotherapeutic treatment. No standardized management protocol has been established for the treatment of GTS. The effect of chemotherapeutic agents for decreasing the volume of and prevention of expansion is unknown. We review in detail the history, diagnostic algorithm, and previous reported pediatric cases as well as treatment options for pediatric patients with GTS. |
| format | Article |
| id | doaj-art-1898face9bd348699a27720ea47d74b7 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-1898face9bd348699a27720ea47d74b72025-02-03T07:24:55ZengWileyCase Reports in Surgery2090-69002090-69192017-01-01201710.1155/2017/30742403074240Pediatric Ovarian Growing Teratoma SyndromeRebecca M. Rentea0Aaron Varghese1Atif Ahmed2Alexander Kats3Michelle Manalang4Tazim Dowlut-McElroy5Richard J. Hendrickson6Department of Surgery, Children’s Mercy Hospital, Kansas City, MO, USADepartment of Obstetrics and Gynecology, University of Missouri, Kansas City, Kansas City, MO, USADepartment of Pathology, Children’s Mercy Hospital, Kansas City, MO, USADepartment of Pathology, Children’s Mercy Hospital, Kansas City, MO, USADepartment of Hematology, Oncology, and Bone Marrow Transplantation, Children’s Mercy Hospital, Kansas City, MO, USADepartment of Obstetrics and Gynecology, University of Missouri, Kansas City, Kansas City, MO, USADepartment of Surgery, Children’s Mercy Hospital, Kansas City, MO, USAOvarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation. Current treatment modality is surgical resection. We discuss a 12-year-old female who presented following resection of a pure ovarian immature teratoma (grade 3, FIGO stage IIIC). Following chemotherapy and resection of a pelvic/liver recurrence demonstrating mature teratoma, she underwent molecular genetics based chemotherapeutic treatment. No standardized management protocol has been established for the treatment of GTS. The effect of chemotherapeutic agents for decreasing the volume of and prevention of expansion is unknown. We review in detail the history, diagnostic algorithm, and previous reported pediatric cases as well as treatment options for pediatric patients with GTS.http://dx.doi.org/10.1155/2017/3074240 |
| spellingShingle | Rebecca M. Rentea Aaron Varghese Atif Ahmed Alexander Kats Michelle Manalang Tazim Dowlut-McElroy Richard J. Hendrickson Pediatric Ovarian Growing Teratoma Syndrome Case Reports in Surgery |
| title | Pediatric Ovarian Growing Teratoma Syndrome |
| title_full | Pediatric Ovarian Growing Teratoma Syndrome |
| title_fullStr | Pediatric Ovarian Growing Teratoma Syndrome |
| title_full_unstemmed | Pediatric Ovarian Growing Teratoma Syndrome |
| title_short | Pediatric Ovarian Growing Teratoma Syndrome |
| title_sort | pediatric ovarian growing teratoma syndrome |
| url | http://dx.doi.org/10.1155/2017/3074240 |
| work_keys_str_mv | AT rebeccamrentea pediatricovariangrowingteratomasyndrome AT aaronvarghese pediatricovariangrowingteratomasyndrome AT atifahmed pediatricovariangrowingteratomasyndrome AT alexanderkats pediatricovariangrowingteratomasyndrome AT michellemanalang pediatricovariangrowingteratomasyndrome AT tazimdowlutmcelroy pediatricovariangrowingteratomasyndrome AT richardjhendrickson pediatricovariangrowingteratomasyndrome |