Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly
BACKGROUND: Behavioral and psychological symptoms in dementia (BPSD) contribute to caregiver burden and institutionalization of elderly. Neuroleptics are prescribed to control agitation. Side effects of typical neuroleptics are harmful, making atypical neuroleptics an indication. OBJECTIVES: To eval...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2001-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000600005&tlng=en |
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| author | Jerson Laks Eliasz Engelhardt Valeska Marinho Marcia Rozenthal Fernando de Castro e Souza Josué Bacaltchuk Alberto Stoppe Jr. R.C.R. Ferreira Cassio Bottino Mônica Scalco |
| author_facet | Jerson Laks Eliasz Engelhardt Valeska Marinho Marcia Rozenthal Fernando de Castro e Souza Josué Bacaltchuk Alberto Stoppe Jr. R.C.R. Ferreira Cassio Bottino Mônica Scalco |
| author_sort | Jerson Laks |
| collection | DOAJ |
| description | BACKGROUND: Behavioral and psychological symptoms in dementia (BPSD) contribute to caregiver burden and institutionalization of elderly. Neuroleptics are prescribed to control agitation. Side effects of typical neuroleptics are harmful, making atypical neuroleptics an indication. OBJECTIVES: To evaluate efficacy and tolerability of risperidone oral solution (ROS) given once daily to demented elderly outpatients with BPSD (agitation). METHOD: Patients (n=26), 76.35±8.63 years, Diagnostic and Statistical Manual of Mental Disorders 4th ed. (DSM-IV) criteria for dementia. RSO was given, starting dose of 0.25 mg and increments of 0.25 mg every week. Mini-Mental State Examination (MMSE) assessed cognitive status, Behavioral and Emotional Activities Manifested in Dementia (BEAM-D) and Clinical Global Impression (CGI) measured BPSD, Extrapiramidal Symptom Rating Scale (ESRS) evaluated extrapyramidal symptoms. Cardiovascular side effects were evaluated clinically. RESULTS: There was a 26% reduction in agitation and no cardiovascular side effects in the range from 1.0 to 1.25 mg. Side effects were more prevalent above 2.5 mg. CONCLUSION: Risperidone oral solution improved agitation with good tolerability from 0.5 to 1.25 mg. A single dose with increments of 0.25 mg may be more acceptable to patients and caregivers. |
| format | Article |
| id | doaj-art-188a039a7d324b3e8a3d25d62faa7a8f |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2001-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-188a039a7d324b3e8a3d25d62faa7a8f2025-08-20T01:58:42ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272001-12-0159485986410.1590/S0004-282X2001000600005Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderlyJerson Laks0Eliasz Engelhardt1Valeska Marinho2Marcia Rozenthal3Fernando de Castro e Souza4Josué Bacaltchuk5Alberto Stoppe Jr.6R.C.R. Ferreira7Cassio Bottino8Mônica Scalco9Universidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloBACKGROUND: Behavioral and psychological symptoms in dementia (BPSD) contribute to caregiver burden and institutionalization of elderly. Neuroleptics are prescribed to control agitation. Side effects of typical neuroleptics are harmful, making atypical neuroleptics an indication. OBJECTIVES: To evaluate efficacy and tolerability of risperidone oral solution (ROS) given once daily to demented elderly outpatients with BPSD (agitation). METHOD: Patients (n=26), 76.35±8.63 years, Diagnostic and Statistical Manual of Mental Disorders 4th ed. (DSM-IV) criteria for dementia. RSO was given, starting dose of 0.25 mg and increments of 0.25 mg every week. Mini-Mental State Examination (MMSE) assessed cognitive status, Behavioral and Emotional Activities Manifested in Dementia (BEAM-D) and Clinical Global Impression (CGI) measured BPSD, Extrapiramidal Symptom Rating Scale (ESRS) evaluated extrapyramidal symptoms. Cardiovascular side effects were evaluated clinically. RESULTS: There was a 26% reduction in agitation and no cardiovascular side effects in the range from 1.0 to 1.25 mg. Side effects were more prevalent above 2.5 mg. CONCLUSION: Risperidone oral solution improved agitation with good tolerability from 0.5 to 1.25 mg. A single dose with increments of 0.25 mg may be more acceptable to patients and caregivers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000600005&tlng=enrisperidonedementiaBPSDelderly |
| spellingShingle | Jerson Laks Eliasz Engelhardt Valeska Marinho Marcia Rozenthal Fernando de Castro e Souza Josué Bacaltchuk Alberto Stoppe Jr. R.C.R. Ferreira Cassio Bottino Mônica Scalco Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly Arquivos de Neuro-Psiquiatria risperidone dementia BPSD elderly |
| title | Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly |
| title_full | Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly |
| title_fullStr | Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly |
| title_full_unstemmed | Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly |
| title_short | Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly |
| title_sort | efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly |
| topic | risperidone dementia BPSD elderly |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000600005&tlng=en |
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