Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature
The incidence of post-transplantation lymphoproliferative disorder (PTLD) in the adult renal transplant population ranges from 0.7% to 4%. The majority of cases involve a single site and arise, on average, seven months after transplantation. Histopathology usually reveals B-cell proliferative diseas...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/135385 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551997525458944 |
|---|---|
| author | CL Nash LM Price DA Stewart F Sepandj S Yilmaz A Barama |
| author_facet | CL Nash LM Price DA Stewart F Sepandj S Yilmaz A Barama |
| author_sort | CL Nash |
| collection | DOAJ |
| description | The incidence of post-transplantation lymphoproliferative disorder (PTLD) in the adult renal transplant population ranges from 0.7% to 4%. The majority of cases involve a single site and arise, on average, seven months after transplantation. Histopathology usually reveals B-cell proliferative disease and has been standardized into its own classification. Treatment modalities consist of decreased immunosuppression, eradication of Epstein-Barr virus, surgical resection, systemic chemotherapy and monoclonal antibody therapy; however, mortality remains high, typically with a short survival time. In patients who have undergone renal transplantation, approximately 10% of those with PTLDs present with gastrointestinal symptomatology and disease. Reported sites include the stomach, and small and large bowel. Very few cases of Helicobacter pylori or mucosal-associated lymphoid tissue have been described in association with PTLD. In the era of cyclosporine immunosuppression, the incidence of PTLD affecting the gastrointestinal tract may be increasing in comparison with the incidence seen with the use of older immunosuppression regimens. A case of antral PTLD and H pylori infection occurring three months after renal transplantation is presented, and the natural history and management of gastric PTLD are reviewed. |
| format | Article |
| id | doaj-art-1886b9f393e74e0c929ca7873356dc3e |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-1886b9f393e74e0c929ca7873356dc3e2025-02-03T05:59:52ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114872172410.1155/2000/135385Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the LiteratureCL Nash0LM Price1DA Stewart2F Sepandj3S Yilmaz4A Barama5Department of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaDepartment of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaDepartment of oncology, University of Calgary, Calgary, Alberta, CanadaDepartment of Nephrology, University of Calgary, Calgary, Alberta, CanadaDivision of Transplantation Surgery, University of Calgary, Calgary, Alberta, CanadaDivision of Transplantation Surgery, University of Calgary, Calgary, Alberta, CanadaThe incidence of post-transplantation lymphoproliferative disorder (PTLD) in the adult renal transplant population ranges from 0.7% to 4%. The majority of cases involve a single site and arise, on average, seven months after transplantation. Histopathology usually reveals B-cell proliferative disease and has been standardized into its own classification. Treatment modalities consist of decreased immunosuppression, eradication of Epstein-Barr virus, surgical resection, systemic chemotherapy and monoclonal antibody therapy; however, mortality remains high, typically with a short survival time. In patients who have undergone renal transplantation, approximately 10% of those with PTLDs present with gastrointestinal symptomatology and disease. Reported sites include the stomach, and small and large bowel. Very few cases of Helicobacter pylori or mucosal-associated lymphoid tissue have been described in association with PTLD. In the era of cyclosporine immunosuppression, the incidence of PTLD affecting the gastrointestinal tract may be increasing in comparison with the incidence seen with the use of older immunosuppression regimens. A case of antral PTLD and H pylori infection occurring three months after renal transplantation is presented, and the natural history and management of gastric PTLD are reviewed.http://dx.doi.org/10.1155/2000/135385 |
| spellingShingle | CL Nash LM Price DA Stewart F Sepandj S Yilmaz A Barama Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature Canadian Journal of Gastroenterology |
| title | Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature |
| title_full | Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature |
| title_fullStr | Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature |
| title_full_unstemmed | Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature |
| title_short | Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature |
| title_sort | early gastric post transplant lymphoproliferative disorder and h pylori detection after kidney transplantation a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2000/135385 |
| work_keys_str_mv | AT clnash earlygastricposttransplantlymphoproliferativedisorderandhpyloridetectionafterkidneytransplantationacasereportandreviewoftheliterature AT lmprice earlygastricposttransplantlymphoproliferativedisorderandhpyloridetectionafterkidneytransplantationacasereportandreviewoftheliterature AT dastewart earlygastricposttransplantlymphoproliferativedisorderandhpyloridetectionafterkidneytransplantationacasereportandreviewoftheliterature AT fsepandj earlygastricposttransplantlymphoproliferativedisorderandhpyloridetectionafterkidneytransplantationacasereportandreviewoftheliterature AT syilmaz earlygastricposttransplantlymphoproliferativedisorderandhpyloridetectionafterkidneytransplantationacasereportandreviewoftheliterature AT abarama earlygastricposttransplantlymphoproliferativedisorderandhpyloridetectionafterkidneytransplantationacasereportandreviewoftheliterature |