A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases
Nutritional interventions facilitating the consumption of natural, affordable, and environment-compatible health-promoting functional foods are a promising strategy for controlling non-communicable diseases. Given that the complex of tomato micronutrients produces healthier outcomes than lycopene, i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1519905/full |
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| author | Pier Giorgio Natali Pier Giorgio Natali Mauro Piantelli Alessandra Sottini Margherita Eufemi Cristina Banfi Luisa Imberti |
| author_facet | Pier Giorgio Natali Pier Giorgio Natali Mauro Piantelli Alessandra Sottini Margherita Eufemi Cristina Banfi Luisa Imberti |
| author_sort | Pier Giorgio Natali |
| collection | DOAJ |
| description | Nutritional interventions facilitating the consumption of natural, affordable, and environment-compatible health-promoting functional foods are a promising strategy for controlling non-communicable diseases. Given that the complex of tomato micronutrients produces healthier outcomes than lycopene, its major antioxidant component, new strategies to improve the health-supporting properties of the berry are ongoing. In this context, a whole tomato food supplement (WTFS), enriched by 2% olive wastewater containing a complex of healthy nutrients with converging biologic activities, has recently been developed, which is superior to those present in tomato commodities or obtained with whole tomato conventional processing methods. WTFS equals the antioxidant activity of N-acetyl-cysteine and interferes with multiple inflammation and cellular transformation-sustaining metabolic pathways. In interventional studies, WTFS inhibits prostate experimental tumors and improves benign prostate hypertrophy-associated symptoms with no associated side-effects. Although WTFS may be susceptible to further improvements and clinical scrutiny, its composition embodies the features of advanced functional foods to ease adherence to dietary patterns, that is, the Mediterranean diet, aimed at contrasting and mitigating the low-grade inflammation, thus being interceptive or preventive of non-communicable diseases. |
| format | Article |
| id | doaj-art-1878178c167b4d59a9766625e08a6bde |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-1878178c167b4d59a9766625e08a6bde2025-02-05T05:17:51ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15199051519905A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseasesPier Giorgio Natali0Pier Giorgio Natali1Mauro Piantelli2Alessandra Sottini3Margherita Eufemi4Cristina Banfi5Luisa Imberti6Mediterranean Task Force for Cancer Control, Rome, ItalyDepartment of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), G. D'Annunzio University, Chieti, ItalyDepartment of Medicine and Aging Sciences, Center for Advanced Studies and Technology (CAST), G. D'Annunzio University, Chieti, ItalyService Department, Highly Specialized Laboratory, Diagnostic Department, ASST Spedali Civili of Brescia, Brescia, ItalyDepartment of Biochemical Science "A. Rossi Fanelli", Faculty of Pharmacy and Medicine, "La Sapienza" University of Rome, Rome, ItalyCentro Cardiologico Monzino IRCCS, Unit of Functional Proteomics, Metabolomics, and Network Analysis, Milan, ItalySection of Microbiology, University of Brescia, P. le Spedali Civili, Brescia, ItalyNutritional interventions facilitating the consumption of natural, affordable, and environment-compatible health-promoting functional foods are a promising strategy for controlling non-communicable diseases. Given that the complex of tomato micronutrients produces healthier outcomes than lycopene, its major antioxidant component, new strategies to improve the health-supporting properties of the berry are ongoing. In this context, a whole tomato food supplement (WTFS), enriched by 2% olive wastewater containing a complex of healthy nutrients with converging biologic activities, has recently been developed, which is superior to those present in tomato commodities or obtained with whole tomato conventional processing methods. WTFS equals the antioxidant activity of N-acetyl-cysteine and interferes with multiple inflammation and cellular transformation-sustaining metabolic pathways. In interventional studies, WTFS inhibits prostate experimental tumors and improves benign prostate hypertrophy-associated symptoms with no associated side-effects. Although WTFS may be susceptible to further improvements and clinical scrutiny, its composition embodies the features of advanced functional foods to ease adherence to dietary patterns, that is, the Mediterranean diet, aimed at contrasting and mitigating the low-grade inflammation, thus being interceptive or preventive of non-communicable diseases.https://www.frontiersin.org/articles/10.3389/fnut.2025.1519905/fullantioxidantfunctional foodmediterranean dietnon-communicable diseasestomato |
| spellingShingle | Pier Giorgio Natali Pier Giorgio Natali Mauro Piantelli Alessandra Sottini Margherita Eufemi Cristina Banfi Luisa Imberti A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases Frontiers in Nutrition antioxidant functional food mediterranean diet non-communicable diseases tomato |
| title | A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases |
| title_full | A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases |
| title_fullStr | A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases |
| title_full_unstemmed | A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases |
| title_short | A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases |
| title_sort | step forward in enhancing the health promoting properties of whole tomato as a functional food to lower the impact of non communicable diseases |
| topic | antioxidant functional food mediterranean diet non-communicable diseases tomato |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1519905/full |
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