Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage
Ocular bacterial infections are universally treated with antibiotics, which can eliminate the organism but cannot reverse the damage caused by bacterial products already present. The three very common causes of bacterial keratitis—Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneu...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/369094 |
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| _version_ | 1832565354106191872 |
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| author | Mary E. Marquart Richard J. O'Callaghan |
| author_facet | Mary E. Marquart Richard J. O'Callaghan |
| author_sort | Mary E. Marquart |
| collection | DOAJ |
| description | Ocular bacterial infections are universally treated with antibiotics, which can eliminate the organism but cannot reverse the damage caused by bacterial products already present. The three very common causes of bacterial keratitis—Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae—all produce proteins that directly or indirectly cause damage to the cornea that can result in reduced vision despite antibiotic treatment. Most, but not all, of these proteins are secreted toxins and enzymes that mediate host cell death, degradation of stromal collagen, cleavage of host cell surface molecules, or induction of a damaging inflammatory response. Studies of these bacterial pathogens have determined the proteins of interest that could be targets for future therapeutic options for decreasing corneal damage. |
| format | Article |
| id | doaj-art-18720c776b8d443495a1cc467c8e693d |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-18720c776b8d443495a1cc467c8e693d2025-02-03T01:07:49ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/369094369094Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal DamageMary E. Marquart0Richard J. O'Callaghan1Department of Microbiology, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USADepartment of Microbiology, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USAOcular bacterial infections are universally treated with antibiotics, which can eliminate the organism but cannot reverse the damage caused by bacterial products already present. The three very common causes of bacterial keratitis—Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae—all produce proteins that directly or indirectly cause damage to the cornea that can result in reduced vision despite antibiotic treatment. Most, but not all, of these proteins are secreted toxins and enzymes that mediate host cell death, degradation of stromal collagen, cleavage of host cell surface molecules, or induction of a damaging inflammatory response. Studies of these bacterial pathogens have determined the proteins of interest that could be targets for future therapeutic options for decreasing corneal damage.http://dx.doi.org/10.1155/2013/369094 |
| spellingShingle | Mary E. Marquart Richard J. O'Callaghan Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage Journal of Ophthalmology |
| title | Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage |
| title_full | Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage |
| title_fullStr | Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage |
| title_full_unstemmed | Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage |
| title_short | Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage |
| title_sort | infectious keratitis secreted bacterial proteins that mediate corneal damage |
| url | http://dx.doi.org/10.1155/2013/369094 |
| work_keys_str_mv | AT maryemarquart infectiouskeratitissecretedbacterialproteinsthatmediatecornealdamage AT richardjocallaghan infectiouskeratitissecretedbacterialproteinsthatmediatecornealdamage |