The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China
Background. Despite a rapid popular of early onset type 2 diabetes (defined as diagnosis at <40 years old) recently, there is a lack of studies on this population in economically undeveloped area. We aimed to investigate the risk factors of macrovascular complications in the early onset T2DM pati...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/3089317 |
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| author | Mingchen Zhang Jiangfeng Mao Ablikm Tuerdi Xiaoyun Zeng Li Quan Shan Xiao Jun Zhu Hua Yao |
| author_facet | Mingchen Zhang Jiangfeng Mao Ablikm Tuerdi Xiaoyun Zeng Li Quan Shan Xiao Jun Zhu Hua Yao |
| author_sort | Mingchen Zhang |
| collection | DOAJ |
| description | Background. Despite a rapid popular of early onset type 2 diabetes (defined as diagnosis at <40 years old) recently, there is a lack of studies on this population in economically undeveloped area. We aimed to investigate the risk factors of macrovascular complications in the early onset T2DM patients in Xinjiang, China. Methods. A cross-sectional survey of 1736 consecutive patients with T2DM was conducted. Macrovascular complications and risk factors were documented. Another nondiabetic population matched with age and sex was as a control group. Logistic regression analysis was performed to obtain odds ratios (OR) for macrovascular complications in early and late onset T2DM, respectively. Results. The final analysis consisted of 1036 late onset and 219 early onset T2DM patients. The mean HbA1c in the early onset group was higher than that in the late onset group (9.1 ± 2.4% versus 8.3 ± 2.2%, P=0.039) despite a higher proportion of patients in the early onset group receiving insulin treatment (73.1% versus 58.7%, P<0.001). Compared to the control, early onset patients had higher blood pressure and worse lipid profiles (all P<0.01). More than half of the early onset T2DM patients already had macro- and microvascular complications, despite of their young age (39.5 ± 10.8) and short DM duration (6.6 ± 8.0). In the early onset group, women had a ~3-fold hazard of atherosclerotic plaques compared with men (OR 3.22, 95% CI 1.53–6.78). Conclusions. Patients with early onset T2DM have worse glycemic control and higher burden of atherogenic risk factors. The prevalence of macro- and microvascular complications is astonishingly high in these young adults with T2DM. Moreover, young women with T2DM are more susceptible to cardiovascular complications than their male counterpart. |
| format | Article |
| id | doaj-art-186f1f07a2284c539ea069386d7b546b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-186f1f07a2284c539ea069386d7b546b2025-02-03T01:01:11ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/30893173089317The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, ChinaMingchen Zhang0Jiangfeng Mao1Ablikm Tuerdi2Xiaoyun Zeng3Li Quan4Shan Xiao5Jun Zhu6Hua Yao7Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Key Laboratory of Endocrinology, Ministry of Health, Beijing, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaPostdoctoral Research Station of Public Health, School of Public Health, Xinjiang Medical University, Urumqi, ChinaBackground. Despite a rapid popular of early onset type 2 diabetes (defined as diagnosis at <40 years old) recently, there is a lack of studies on this population in economically undeveloped area. We aimed to investigate the risk factors of macrovascular complications in the early onset T2DM patients in Xinjiang, China. Methods. A cross-sectional survey of 1736 consecutive patients with T2DM was conducted. Macrovascular complications and risk factors were documented. Another nondiabetic population matched with age and sex was as a control group. Logistic regression analysis was performed to obtain odds ratios (OR) for macrovascular complications in early and late onset T2DM, respectively. Results. The final analysis consisted of 1036 late onset and 219 early onset T2DM patients. The mean HbA1c in the early onset group was higher than that in the late onset group (9.1 ± 2.4% versus 8.3 ± 2.2%, P=0.039) despite a higher proportion of patients in the early onset group receiving insulin treatment (73.1% versus 58.7%, P<0.001). Compared to the control, early onset patients had higher blood pressure and worse lipid profiles (all P<0.01). More than half of the early onset T2DM patients already had macro- and microvascular complications, despite of their young age (39.5 ± 10.8) and short DM duration (6.6 ± 8.0). In the early onset group, women had a ~3-fold hazard of atherosclerotic plaques compared with men (OR 3.22, 95% CI 1.53–6.78). Conclusions. Patients with early onset T2DM have worse glycemic control and higher burden of atherogenic risk factors. The prevalence of macro- and microvascular complications is astonishingly high in these young adults with T2DM. Moreover, young women with T2DM are more susceptible to cardiovascular complications than their male counterpart.http://dx.doi.org/10.1155/2018/3089317 |
| spellingShingle | Mingchen Zhang Jiangfeng Mao Ablikm Tuerdi Xiaoyun Zeng Li Quan Shan Xiao Jun Zhu Hua Yao The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China Journal of Diabetes Research |
| title | The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China |
| title_full | The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China |
| title_fullStr | The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China |
| title_full_unstemmed | The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China |
| title_short | The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China |
| title_sort | constellation of macrovascular risk factors in early onset t2dm a cross sectional study in xinjiang province china |
| url | http://dx.doi.org/10.1155/2018/3089317 |
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