Efficacy and Safety of Pegcetacoplan in Kidney Transplant Recipients With Recurrent Complement 3 Glomerulopathy or Primary Immune Complex Membranoproliferative Glomerulonephritis

Efficacy and Safety of Pegcetacoplan in Kidney Transplant Recipients With Recurrent Complement 3 Glomerulopathy or Primary Immune Complex Membranoproliferative Glomerulonephritis

Introduction: Complement 3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) have high risks for disease recurrence and allograft loss in transplant kidneys. Pegcetacoplan (targeted complement 3 [C3]/C3b inhibitor) may prevent excessive deposition of...

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Main Authors: Andrew S. Bomback, Erica Daina, Giuseppe Remuzzi, John Kanellis, David Kavanagh, Matthew C. Pickering, Gere Sunder-Plassmann, Patrick D. Walker, Zhongshen Wang, Zurish Ahmad, Fadi Fakhouri
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Kidney International Reports
Subjects:
C3 glomerulopathy
complement
immune complex membranoproliferative glomerulonephritis
pegcetacoplan
proteinuria
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924019612
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