Competing Endogenous RNA: The Key to Posttranscriptional Regulation
Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long no...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/896206 |
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| author | Rituparno Sen Suman Ghosal Shaoli Das Subrata Balti Jayprokas Chakrabarti |
| author_facet | Rituparno Sen Suman Ghosal Shaoli Das Subrata Balti Jayprokas Chakrabarti |
| author_sort | Rituparno Sen |
| collection | DOAJ |
| description | Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA “sponges” by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA. These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression. ceRNAs are widely implicated in many biological processes. Recent studies have identified ceRNAs associated with a number of diseases including cancer. This brief review focuses on the molecular mechanism of ceRNA as part of the complex post-transcriptional regulatory circuit in cell and the impact of ceRNAs in development and disease. |
| format | Article |
| id | doaj-art-1863541ca79d4f11991f498ebea702f3 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1863541ca79d4f11991f498ebea702f32025-02-03T01:31:43ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/896206896206Competing Endogenous RNA: The Key to Posttranscriptional RegulationRituparno Sen0Suman Ghosal1Shaoli Das2Subrata Balti3Jayprokas Chakrabarti4Gyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, IndiaIndian Association for the Cultivation of Science, Kolkata, West Bengal 700032, IndiaIndian Association for the Cultivation of Science, Kolkata, West Bengal 700032, IndiaIndian Association for the Cultivation of Science, Kolkata, West Bengal 700032, IndiaGyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, IndiaCompeting endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA “sponges” by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA. These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression. ceRNAs are widely implicated in many biological processes. Recent studies have identified ceRNAs associated with a number of diseases including cancer. This brief review focuses on the molecular mechanism of ceRNA as part of the complex post-transcriptional regulatory circuit in cell and the impact of ceRNAs in development and disease.http://dx.doi.org/10.1155/2014/896206 |
| spellingShingle | Rituparno Sen Suman Ghosal Shaoli Das Subrata Balti Jayprokas Chakrabarti Competing Endogenous RNA: The Key to Posttranscriptional Regulation The Scientific World Journal |
| title | Competing Endogenous RNA: The Key to Posttranscriptional Regulation |
| title_full | Competing Endogenous RNA: The Key to Posttranscriptional Regulation |
| title_fullStr | Competing Endogenous RNA: The Key to Posttranscriptional Regulation |
| title_full_unstemmed | Competing Endogenous RNA: The Key to Posttranscriptional Regulation |
| title_short | Competing Endogenous RNA: The Key to Posttranscriptional Regulation |
| title_sort | competing endogenous rna the key to posttranscriptional regulation |
| url | http://dx.doi.org/10.1155/2014/896206 |
| work_keys_str_mv | AT rituparnosen competingendogenousrnathekeytoposttranscriptionalregulation AT sumanghosal competingendogenousrnathekeytoposttranscriptionalregulation AT shaolidas competingendogenousrnathekeytoposttranscriptionalregulation AT subratabalti competingendogenousrnathekeytoposttranscriptionalregulation AT jayprokaschakrabarti competingendogenousrnathekeytoposttranscriptionalregulation |