Assessing brain morphological correlates of premenstrual symptoms in young healthy females
While 90 % of females with a menstrual cycle will experience premenstrual symptoms in their reproductive years, it is estimated that 20 % experience treatment-warranted emotional, behavioral, or somatic symptoms in the premenstrual phase of their menstrual cycle. Premenstrual symptoms have been part...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915325000460 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849310415053389824 |
|---|---|
| author | Sara B. Marjanovic Madelene Christin Holm Bukhari Rikka Kjelkenes Irene Voldsbekk Claudia Barth Lars T. Westlye |
| author_facet | Sara B. Marjanovic Madelene Christin Holm Bukhari Rikka Kjelkenes Irene Voldsbekk Claudia Barth Lars T. Westlye |
| author_sort | Sara B. Marjanovic |
| collection | DOAJ |
| description | While 90 % of females with a menstrual cycle will experience premenstrual symptoms in their reproductive years, it is estimated that 20 % experience treatment-warranted emotional, behavioral, or somatic symptoms in the premenstrual phase of their menstrual cycle. Premenstrual symptoms have been partly attributed to the brain's sensitivity to menstrual cycle-related hormonal fluctuations, which may be modulated by individual differences in the structural characteristics of the brain. In a population-based sample of 292 non-pregnant females aged 23–43 years, we tested for associations between self-reported premenstrual symptom load and T1-weighted MRI based brain measures of cortical thickness, volume, and surface area as well as subcortical volumes, not controlling for menstrual cycle phase. After corrections for multiple comparison, linear models including age revealed significant positive associations between premenstrual symptom load and the volume of the left posterior cingulate cortex. Item-level analyses confirmed that the association with overall symptom load were not driven by specific symptom domains. These findings partly overlap with previous brain morphological findings in individuals with PMS and could possibly represent a non-phase dependent correlate of premenstrual symptoms. |
| format | Article |
| id | doaj-art-1858a71db6454058b2586ea27116be36 |
| institution | Kabale University |
| issn | 2666-9153 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj-art-1858a71db6454058b2586ea27116be362025-08-20T03:53:43ZengElsevierJournal of Affective Disorders Reports2666-91532025-04-012010091610.1016/j.jadr.2025.100916Assessing brain morphological correlates of premenstrual symptoms in young healthy femalesSara B. Marjanovic0Madelene Christin Holm Bukhari1Rikka Kjelkenes2Irene Voldsbekk3Claudia Barth4Lars T. Westlye5Department of Psychology, University of Oslo, Oslo, Norway; Corresponding authors: Department of Psychology, University of Oslo, PoBox 1094 Blindern 0317 Oslo, Norway.Department of Psychology, University of Oslo, Oslo, NorwayDepartment of Psychology, University of Oslo, Oslo, NorwayDepartment of Psychology, University of Oslo, Oslo, Norway; Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NorwayDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NorwayDepartment of Psychology, University of Oslo, Oslo, Norway; Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Norway; Corresponding authors: Department of Psychology, University of Oslo, PoBox 1094 Blindern 0317 Oslo, Norway.While 90 % of females with a menstrual cycle will experience premenstrual symptoms in their reproductive years, it is estimated that 20 % experience treatment-warranted emotional, behavioral, or somatic symptoms in the premenstrual phase of their menstrual cycle. Premenstrual symptoms have been partly attributed to the brain's sensitivity to menstrual cycle-related hormonal fluctuations, which may be modulated by individual differences in the structural characteristics of the brain. In a population-based sample of 292 non-pregnant females aged 23–43 years, we tested for associations between self-reported premenstrual symptom load and T1-weighted MRI based brain measures of cortical thickness, volume, and surface area as well as subcortical volumes, not controlling for menstrual cycle phase. After corrections for multiple comparison, linear models including age revealed significant positive associations between premenstrual symptom load and the volume of the left posterior cingulate cortex. Item-level analyses confirmed that the association with overall symptom load were not driven by specific symptom domains. These findings partly overlap with previous brain morphological findings in individuals with PMS and could possibly represent a non-phase dependent correlate of premenstrual symptoms.http://www.sciencedirect.com/science/article/pii/S2666915325000460BrainPremenstrual syndromePremenstrual symptomsMRINeuroimaging |
| spellingShingle | Sara B. Marjanovic Madelene Christin Holm Bukhari Rikka Kjelkenes Irene Voldsbekk Claudia Barth Lars T. Westlye Assessing brain morphological correlates of premenstrual symptoms in young healthy females Journal of Affective Disorders Reports Brain Premenstrual syndrome Premenstrual symptoms MRI Neuroimaging |
| title | Assessing brain morphological correlates of premenstrual symptoms in young healthy females |
| title_full | Assessing brain morphological correlates of premenstrual symptoms in young healthy females |
| title_fullStr | Assessing brain morphological correlates of premenstrual symptoms in young healthy females |
| title_full_unstemmed | Assessing brain morphological correlates of premenstrual symptoms in young healthy females |
| title_short | Assessing brain morphological correlates of premenstrual symptoms in young healthy females |
| title_sort | assessing brain morphological correlates of premenstrual symptoms in young healthy females |
| topic | Brain Premenstrual syndrome Premenstrual symptoms MRI Neuroimaging |
| url | http://www.sciencedirect.com/science/article/pii/S2666915325000460 |
| work_keys_str_mv | AT sarabmarjanovic assessingbrainmorphologicalcorrelatesofpremenstrualsymptomsinyounghealthyfemales AT madelenechristinholmbukhari assessingbrainmorphologicalcorrelatesofpremenstrualsymptomsinyounghealthyfemales AT rikkakjelkenes assessingbrainmorphologicalcorrelatesofpremenstrualsymptomsinyounghealthyfemales AT irenevoldsbekk assessingbrainmorphologicalcorrelatesofpremenstrualsymptomsinyounghealthyfemales AT claudiabarth assessingbrainmorphologicalcorrelatesofpremenstrualsymptomsinyounghealthyfemales AT larstwestlye assessingbrainmorphologicalcorrelatesofpremenstrualsymptomsinyounghealthyfemales |