A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification
Abstract Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, yet the specific cells responsible for tendon healing remain uncertain. Here we identify a CD26+ tendon stem/progenitor cells residing in peritendon, which constitutes a primitive stem cell p...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56112-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594601141075968 |
|---|---|
| author | Siwen Chen Yingxin Lin Hao Yang Zihao Li Sifang Li Dongying Chen Wenjun Hao Shuai Zhang Hua Chao Jingyu Zhang Jianru Wang Zemin Li Xiang Li Zhongping Zhan Hui Liu |
| author_facet | Siwen Chen Yingxin Lin Hao Yang Zihao Li Sifang Li Dongying Chen Wenjun Hao Shuai Zhang Hua Chao Jingyu Zhang Jianru Wang Zemin Li Xiang Li Zhongping Zhan Hui Liu |
| author_sort | Siwen Chen |
| collection | DOAJ |
| description | Abstract Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, yet the specific cells responsible for tendon healing remain uncertain. Here we identify a CD26+ tendon stem/progenitor cells residing in peritendon, which constitutes a primitive stem cell population with self-renewal and multipotent differentiation potentials. CD26+ tendon stem/progenitor cells migrate into the tendon midsubstance and differentiation into tenocytes during tendon healing, while ablation of these cells led to insufficient tendon healing. Additionally, CD26+ tendon stem/progenitor cells contribute to heterotopic ossification and Tenascin-C-Hippo signaling is involved in this process. Targeting Tenascin-C significantly suppresses chondrogenesis of CD26+ tendon stem/progenitor cells and subsequent heterotopic ossification. Our findings provide insights into the identification of tendon stem/progenitor cells and illustrate the essential role of CD26+ tendon stem/progenitor cells in tendon healing and heterotopic bone formation. |
| format | Article |
| id | doaj-art-184e76d9494b4c8585f6ef3cb2cbf450 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-184e76d9494b4c8585f6ef3cb2cbf4502025-01-19T12:29:46ZengNature PortfolioNature Communications2041-17232025-01-0116111810.1038/s41467-025-56112-5A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossificationSiwen Chen0Yingxin Lin1Hao Yang2Zihao Li3Sifang Li4Dongying Chen5Wenjun Hao6Shuai Zhang7Hua Chao8Jingyu Zhang9Jianru Wang10Zemin Li11Xiang Li12Zhongping Zhan13Hui Liu14Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversitySchool of Mathematics and Statistics, The University of SydneyPediatric Orthopaedics, Beijing Jishuitan Hospital, Peking UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityAbstract Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, yet the specific cells responsible for tendon healing remain uncertain. Here we identify a CD26+ tendon stem/progenitor cells residing in peritendon, which constitutes a primitive stem cell population with self-renewal and multipotent differentiation potentials. CD26+ tendon stem/progenitor cells migrate into the tendon midsubstance and differentiation into tenocytes during tendon healing, while ablation of these cells led to insufficient tendon healing. Additionally, CD26+ tendon stem/progenitor cells contribute to heterotopic ossification and Tenascin-C-Hippo signaling is involved in this process. Targeting Tenascin-C significantly suppresses chondrogenesis of CD26+ tendon stem/progenitor cells and subsequent heterotopic ossification. Our findings provide insights into the identification of tendon stem/progenitor cells and illustrate the essential role of CD26+ tendon stem/progenitor cells in tendon healing and heterotopic bone formation.https://doi.org/10.1038/s41467-025-56112-5 |
| spellingShingle | Siwen Chen Yingxin Lin Hao Yang Zihao Li Sifang Li Dongying Chen Wenjun Hao Shuai Zhang Hua Chao Jingyu Zhang Jianru Wang Zemin Li Xiang Li Zhongping Zhan Hui Liu A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification Nature Communications |
| title | A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification |
| title_full | A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification |
| title_fullStr | A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification |
| title_full_unstemmed | A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification |
| title_short | A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification |
| title_sort | cd26 tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification |
| url | https://doi.org/10.1038/s41467-025-56112-5 |
| work_keys_str_mv | AT siwenchen acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT yingxinlin acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT haoyang acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT zihaoli acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT sifangli acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT dongyingchen acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT wenjunhao acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT shuaizhang acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT huachao acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT jingyuzhang acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT jianruwang acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT zeminli acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT xiangli acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT zhongpingzhan acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT huiliu acd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT siwenchen cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT yingxinlin cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT haoyang cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT zihaoli cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT sifangli cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT dongyingchen cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT wenjunhao cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT shuaizhang cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT huachao cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT jingyuzhang cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT jianruwang cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT zeminli cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT xiangli cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT zhongpingzhan cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification AT huiliu cd26tendonstemprogenitorcellpopulationcontributestotendonrepairandheterotopicossification |