Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma
Determination of markers of systemic inflammation is one of the important directions in the study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchial asthma (BA). The aim of our work was a comparative study of the fea...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/4652898 |
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| author | Nailya Kubysheva Marina Boldina Tatyana Eliseeva Svetlana Soodaeva Igor Klimanov Anastasia Khaletskaya Venera Bayrasheva Valery Solovyev Luis Alfonso Villa-Vargas Marco Antonio Ramírez-Salinas Moisés Salinas-Rosales Dmitry Yu. Ovsyannikov Ildar Batyrshin |
| author_facet | Nailya Kubysheva Marina Boldina Tatyana Eliseeva Svetlana Soodaeva Igor Klimanov Anastasia Khaletskaya Venera Bayrasheva Valery Solovyev Luis Alfonso Villa-Vargas Marco Antonio Ramírez-Salinas Moisés Salinas-Rosales Dmitry Yu. Ovsyannikov Ildar Batyrshin |
| author_sort | Nailya Kubysheva |
| collection | DOAJ |
| description | Determination of markers of systemic inflammation is one of the important directions in the study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchial asthma (BA). The aim of our work was a comparative study of the features of changes in serum levels of IL-17, IL-18, and TNF-α in patients with COPD, ACO, and BA with various severity of the disease, as well as evaluation of the relationship between the level of these cytokines and lung ventilation function. A total of 147 patients with COPD (n=58), ACO (n=57), and BA (n=32) during a stable period have been examined in this study. The control group included 21 healthy nonsmokers with similar sex-age indicators. Serum levels of IL-17, IL-18, and TNF-α were determined by ELISA. The concentrations of these cytokines in the circulation in the studied patients with COPD, ACO, and BA were higher than those in healthy nonsmokers (p≤0.001). IL-17 and IL-18 levels in the blood serum were comparable in all examined patients. The mean TNF-α concentrations in the circulation in COPD and ACO were significantly higher than those in BA (p<0.001). In patients with COPD, the levels of IL-17 and TNF-α increased progressively against the background of a decrease in numerous spirometric indicators, which allows us to consider these cytokines as systemic biomarkers of disease severity. In BA, the inverse correlations between the level of IL-17 and FEV1/FVC (%) and FEV1 have been found. In patients with ACO, the increase in IL-18 levels was associated with a decrease in FEV1 and TNF-α with FEV1/FVC (%). These findings indicate that IL-17, IL-18, and TNF-α can participate in the mechanisms of systemic inflammation and the genesis of disorders of airway obstruction in COPD, AСO, and BA. An increase in the levels of IL-17 and TNF-α may be associated with impaired bronchial patency in COPD and BA. The established associations of the IL-18 concentration in the blood serum and FEV1 only in patients with ACO allow using the level of IL-18 as a potential marker of the degree of impaired airway obstruction in this disease. |
| format | Article |
| id | doaj-art-184a31fc6c45478592807b08e7a58cb4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-184a31fc6c45478592807b08e7a58cb42025-02-03T01:05:21ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/46528984652898Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial AsthmaNailya Kubysheva0Marina Boldina1Tatyana Eliseeva2Svetlana Soodaeva3Igor Klimanov4Anastasia Khaletskaya5Venera Bayrasheva6Valery Solovyev7Luis Alfonso Villa-Vargas8Marco Antonio Ramírez-Salinas9Moisés Salinas-Rosales10Dmitry Yu. Ovsyannikov11Ildar Batyrshin12Kazan Federal University, Kremlyovskaya St., 18, Kazan 420000, RussiaFederal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University, Minin and Pozharsky Square 10/1, Nizhny Novgorod 603005, RussiaFederal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University, Minin and Pozharsky Square 10/1, Nizhny Novgorod 603005, RussiaPulmonology Scientific Research Institute under FMBA of Russia, Orekhovyy Bul’var 28, Moscow 115682, RussiaPulmonology Scientific Research Institute under FMBA of Russia, Orekhovyy Bul’var 28, Moscow 115682, RussiaState Health Facility “City Clinical Hospital No. 5”, St. Nesterova, 34, Nizhny Novgorod 603005, RussiaKazan Federal University, Kremlyovskaya St., 18, Kazan 420000, RussiaKazan Federal University, Kremlyovskaya St., 18, Kazan 420000, RussiaInstituto Politecnico Nacional, Av. Juan de Dios Bátiz, Esq. Miguel Othón de Mendizábal, Col. Nueva Industrial Vallejo, Alcaldía Gustavo A. Madero, 07738 Mexico City, MexicoCentro de Investigación en Computación, Instituto Politécnico Nacional (CIC-IPN), Av. Juan de Dios Bátiz, Esq. Miguel Othón de Mendizábal S/N, Gustavo A. Madero, 07738 Mexico City, MexicoCentro de Investigación en Computación, Instituto Politécnico Nacional (CIC-IPN), Av. Juan de Dios Bátiz, Esq. Miguel Othón de Mendizábal S/N, Gustavo A. Madero, 07738 Mexico City, MexicoDepartment of Pediatrics, Medical Institute, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow 117198, RussiaCentro de Investigación en Computación, Instituto Politécnico Nacional (CIC-IPN), Av. Juan de Dios Bátiz, Esq. Miguel Othón de Mendizábal S/N, Gustavo A. Madero, 07738 Mexico City, MexicoDetermination of markers of systemic inflammation is one of the important directions in the study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchial asthma (BA). The aim of our work was a comparative study of the features of changes in serum levels of IL-17, IL-18, and TNF-α in patients with COPD, ACO, and BA with various severity of the disease, as well as evaluation of the relationship between the level of these cytokines and lung ventilation function. A total of 147 patients with COPD (n=58), ACO (n=57), and BA (n=32) during a stable period have been examined in this study. The control group included 21 healthy nonsmokers with similar sex-age indicators. Serum levels of IL-17, IL-18, and TNF-α were determined by ELISA. The concentrations of these cytokines in the circulation in the studied patients with COPD, ACO, and BA were higher than those in healthy nonsmokers (p≤0.001). IL-17 and IL-18 levels in the blood serum were comparable in all examined patients. The mean TNF-α concentrations in the circulation in COPD and ACO were significantly higher than those in BA (p<0.001). In patients with COPD, the levels of IL-17 and TNF-α increased progressively against the background of a decrease in numerous spirometric indicators, which allows us to consider these cytokines as systemic biomarkers of disease severity. In BA, the inverse correlations between the level of IL-17 and FEV1/FVC (%) and FEV1 have been found. In patients with ACO, the increase in IL-18 levels was associated with a decrease in FEV1 and TNF-α with FEV1/FVC (%). These findings indicate that IL-17, IL-18, and TNF-α can participate in the mechanisms of systemic inflammation and the genesis of disorders of airway obstruction in COPD, AСO, and BA. An increase in the levels of IL-17 and TNF-α may be associated with impaired bronchial patency in COPD and BA. The established associations of the IL-18 concentration in the blood serum and FEV1 only in patients with ACO allow using the level of IL-18 as a potential marker of the degree of impaired airway obstruction in this disease.http://dx.doi.org/10.1155/2020/4652898 |
| spellingShingle | Nailya Kubysheva Marina Boldina Tatyana Eliseeva Svetlana Soodaeva Igor Klimanov Anastasia Khaletskaya Venera Bayrasheva Valery Solovyev Luis Alfonso Villa-Vargas Marco Antonio Ramírez-Salinas Moisés Salinas-Rosales Dmitry Yu. Ovsyannikov Ildar Batyrshin Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma Mediators of Inflammation |
| title | Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma |
| title_full | Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma |
| title_fullStr | Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma |
| title_full_unstemmed | Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma |
| title_short | Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma |
| title_sort | relationship of serum levels of il 17 il 18 tnf α and lung function parameters in patients with copd asthma copd overlap and bronchial asthma |
| url | http://dx.doi.org/10.1155/2020/4652898 |
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