Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles
A series of 1-phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles were synthesized from chalcones, that is, 3-aryl-1-(4-hydroxyphenyl) prop-2-en-1-ones and studied for their in vitro antibacterial activity. Chalcones 1 on reaction with phenyl hydrazine in the presence of acetic acid and few drops...
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/950491 |
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| author | Anju Goyal Sandeep Jain |
| author_facet | Anju Goyal Sandeep Jain |
| author_sort | Anju Goyal |
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| description | A series of 1-phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles were synthesized from chalcones, that is, 3-aryl-1-(4-hydroxyphenyl) prop-2-en-1-ones and studied for their in vitro antibacterial activity. Chalcones 1 on reaction with phenyl hydrazine in the presence of acetic acid and few drops of hydrochloric acid yielded the corresponding 1-phenyl-3-(4-hydroxyphenyl)-5-aryl-1H-pyrazoles 2 which on further reaction with 2-chloroethanol furnished the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa), and their minimum inhibitory concentration (MIC) was determined. |
| format | Article |
| id | doaj-art-1847c0f9c8594923be9fbb5562526ef7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Journal of Chemistry |
| spelling | doaj-art-1847c0f9c8594923be9fbb5562526ef72025-02-03T07:26:19ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/950491950491Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazolesAnju Goyal0Sandeep Jain1Chitkara College of Pharmacy, Patiala, Rajpura 140401, IndiaDrug Discovery and Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, IndiaA series of 1-phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles were synthesized from chalcones, that is, 3-aryl-1-(4-hydroxyphenyl) prop-2-en-1-ones and studied for their in vitro antibacterial activity. Chalcones 1 on reaction with phenyl hydrazine in the presence of acetic acid and few drops of hydrochloric acid yielded the corresponding 1-phenyl-3-(4-hydroxyphenyl)-5-aryl-1H-pyrazoles 2 which on further reaction with 2-chloroethanol furnished the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa), and their minimum inhibitory concentration (MIC) was determined.http://dx.doi.org/10.1155/2013/950491 |
| spellingShingle | Anju Goyal Sandeep Jain Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles Journal of Chemistry |
| title | Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles |
| title_full | Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles |
| title_fullStr | Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles |
| title_full_unstemmed | Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles |
| title_short | Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles |
| title_sort | syntheses and antibacterial studies of some 1 phenyl 3 4 2 ethanoloxy phenyl 5 aryl 1h pyrazoles |
| url | http://dx.doi.org/10.1155/2013/950491 |
| work_keys_str_mv | AT anjugoyal synthesesandantibacterialstudiesofsome1phenyl342ethanoloxyphenyl5aryl1hpyrazoles AT sandeepjain synthesesandantibacterialstudiesofsome1phenyl342ethanoloxyphenyl5aryl1hpyrazoles |