Decoding multiple myeloma: single-cell insights into tumor heterogeneity, immune dynamics, and disease progression

Decoding multiple myeloma: single-cell insights into tumor heterogeneity, immune dynamics, and disease progression

BackgroundMultiple myeloma (MM) is a biologically heterogeneous malignancy of clonal plasma cells, often progressing from MGUS or smoldering MM. It causes anemia, bone lesions, and immune dysfunction due to abnormal plasma cell expansion in the bone marrow. Neuroinflammatory and neurotrophic factors...

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Bibliographic Details
Main Authors: Zhenzhen Zhao, Zhijie Zhao, Zhiheng Lin, Lu Fan, Zhikai Xiahou, Yujiang Dong, Weiying Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
ScRNA-seq
neuroimmunity
NR3C1
IGLC3
APP
MIF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1584350/full
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