RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway

RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway

Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying ER-phagy in the pathogenesis of intervertebral disc degeneration remain largely unclear. In the present study, we demonstrate...

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Bibliographic Details
Main Authors: Luo Rongjin, Liang Huaizhen, Zhang Weifeng, Li Gaocai, Zhao Kangcheng, Hua Wenbin, Song Yu, Yang Cao
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-03-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
intervertebral disc degeneration
senescence
apoptosis
ER-phagy
ER stress
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022024
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