NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway

NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway

Abstract Chronic innate immune activation in the central nervous system (CNS) significantly contributes to neurodegeneration in progressive multiple sclerosis (MS). Using multiple experimental autoimmune encephalomyelitis (EAE) models, we discovered that NLRX1 protects neurons in the anterior visual...

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Main Authors: Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, Sachin P. Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri, Omar Hussein, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
MS
Innate immunity
NLRX1
Neurodegeneration
EAE
Retina
Online Access:https://doi.org/10.1186/s12974-025-03339-0
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https://doi.org/10.1186/s12974-025-03339-0

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