Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols

Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols

Lentiviral vector-transduced T cells were approved by the FDA as gene therapy anti-cancer medications. Little is known about the effects of host genetic variation on the safety and efficacy of the lentiviral vector gene delivery system. To narrow this knowledge gap, we characterized hepatic gene del...

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Bibliographic Details
Main Authors: Peirong Hu, Yajing Hao, Wei Tang, Graham H. Diering, Fei Zou, Tal Kafri
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Viruses
Subjects:
lentiviral vectors
gene therapy
Collaborative Cross
preclinical studies
hepatic transduction
intrastrain variations
Online Access:https://www.mdpi.com/1999-4915/17/2/276
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