Risk factors for inflammatory bowel disease: an umbrella review
IntroductionInflammatory bowel disease (IBD) represents a cluster of chronic idiopathic inflammatory disorders situated at the nexus of intricate interplays. The primary aim of the present investigation is to perform an umbrella review of metaanalyses, systematically offering a comprehensive overvie...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1410506/full |
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| author | Tingping Wu Honghui Cheng Jiamei Zhuang Xianhua Liu Zichen Ouyang Rui Qian |
| author_facet | Tingping Wu Honghui Cheng Jiamei Zhuang Xianhua Liu Zichen Ouyang Rui Qian |
| author_sort | Tingping Wu |
| collection | DOAJ |
| description | IntroductionInflammatory bowel disease (IBD) represents a cluster of chronic idiopathic inflammatory disorders situated at the nexus of intricate interplays. The primary aim of the present investigation is to perform an umbrella review of metaanalyses, systematically offering a comprehensive overview of the evidence concerning risk factors for IBD.MethodsTo achieve this, we searched reputable databases, including PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews, from inception through April 2023. Two authors independently assessed the methodological quality of each metaanalysis using the AMSTAR tool and adhered to evidence classification criteria.ResultsIn total, we extracted 191 unique risk factors in meta-analyses, including 92 significantly associated risk factors. The top ten risk factors were human cytomegalovirus (HCMV) infection, IBD family history, periodontal disease, poliomyelitis, campylobacter species infection, hidradenitis suppurativa, psoriasis, use of proton pump inhibitors, chronic obstructive pulmonary disease, and western dietary pattern.DiscussionIn conclusion, this umbrella review extracted 62 risk factors and 30 protective factors, most of which were related to underlying diseases, personal lifestyle and environmental factors. The findings in this paper help to develop better prevention and treatment measures to reduce the incidence of IBD, delay its progression, and reduce the burden of IBD-related disease worldwide.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023417175. |
| format | Article |
| id | doaj-art-18201bb8be6d4d90b88e8212dcbcdd17 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-18201bb8be6d4d90b88e8212dcbcdd172025-01-24T07:13:54ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14105061410506Risk factors for inflammatory bowel disease: an umbrella reviewTingping Wu0Honghui Cheng1Jiamei Zhuang2Xianhua Liu3Zichen Ouyang4Rui Qian5Shenzhen Bao'an Chinese Medicine Hospital, The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaShenzhen Bao'an Chinese Medicine Hospital, The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaShenzhen Bao'an Chinese Medicine Hospital, The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaShenzhen Bao'an Chinese Medicine Hospital, The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaShenzhen Bao'an Chinese Medicine Hospital, The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaIntroductionInflammatory bowel disease (IBD) represents a cluster of chronic idiopathic inflammatory disorders situated at the nexus of intricate interplays. The primary aim of the present investigation is to perform an umbrella review of metaanalyses, systematically offering a comprehensive overview of the evidence concerning risk factors for IBD.MethodsTo achieve this, we searched reputable databases, including PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews, from inception through April 2023. Two authors independently assessed the methodological quality of each metaanalysis using the AMSTAR tool and adhered to evidence classification criteria.ResultsIn total, we extracted 191 unique risk factors in meta-analyses, including 92 significantly associated risk factors. The top ten risk factors were human cytomegalovirus (HCMV) infection, IBD family history, periodontal disease, poliomyelitis, campylobacter species infection, hidradenitis suppurativa, psoriasis, use of proton pump inhibitors, chronic obstructive pulmonary disease, and western dietary pattern.DiscussionIn conclusion, this umbrella review extracted 62 risk factors and 30 protective factors, most of which were related to underlying diseases, personal lifestyle and environmental factors. The findings in this paper help to develop better prevention and treatment measures to reduce the incidence of IBD, delay its progression, and reduce the burden of IBD-related disease worldwide.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023417175.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1410506/fullinflammatory bowel diseaserisk factorumbrella reviewmeta-analysisIBD |
| spellingShingle | Tingping Wu Honghui Cheng Jiamei Zhuang Xianhua Liu Zichen Ouyang Rui Qian Risk factors for inflammatory bowel disease: an umbrella review Frontiers in Cellular and Infection Microbiology inflammatory bowel disease risk factor umbrella review meta-analysis IBD |
| title | Risk factors for inflammatory bowel disease: an umbrella review |
| title_full | Risk factors for inflammatory bowel disease: an umbrella review |
| title_fullStr | Risk factors for inflammatory bowel disease: an umbrella review |
| title_full_unstemmed | Risk factors for inflammatory bowel disease: an umbrella review |
| title_short | Risk factors for inflammatory bowel disease: an umbrella review |
| title_sort | risk factors for inflammatory bowel disease an umbrella review |
| topic | inflammatory bowel disease risk factor umbrella review meta-analysis IBD |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1410506/full |
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