Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis
Stroke is a severe medical condition resulting from an interruption in the blood supply to the brain, ultimately compromising tissue homeostasis. Currently, stroke stands as the second leading cause of death worldwide and the third leading cause when considering both mortality and disability togethe...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025005389 |
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| author | Victória dos Santos Chemelo Marco Aurelio M. Freire Leonardo Oliveira Bittencourt Deborah Ribeiro Frazão Deiweson Souza-Monteiro Sabrina C. Cartagenes Walace Gomes-Leal Cristiane do Socorro Ferraz Maia Gabriel S. Rocha Daniel Falcao Rafael Rodrigues Lima |
| author_facet | Victória dos Santos Chemelo Marco Aurelio M. Freire Leonardo Oliveira Bittencourt Deborah Ribeiro Frazão Deiweson Souza-Monteiro Sabrina C. Cartagenes Walace Gomes-Leal Cristiane do Socorro Ferraz Maia Gabriel S. Rocha Daniel Falcao Rafael Rodrigues Lima |
| author_sort | Victória dos Santos Chemelo |
| collection | DOAJ |
| description | Stroke is a severe medical condition resulting from an interruption in the blood supply to the brain, ultimately compromising tissue homeostasis. Currently, stroke stands as the second leading cause of death worldwide and the third leading cause when considering both mortality and disability together. Periodontitis is characterized by persistent inflammation in hard and soft tissues which support the teeth, primarily caused by bacterial biofilms, and is one of the most common causes of tooth loss in adults and can contribute to a systemic inflammatory burden. In the light of this, the present study investigated the effects of inducing focal ischemia in the motor cortex in rats undergoing experimental periodontitis. Adult Wistar rats were divided into four groups (control, ischemia, periodontitis, and periodontitis + ischemia) and were evaluated for motor performance, basic histology, and the volume and microarchitecture of alveolar bone. The results showed that the comorbidity between ischemia and periodontitis aggravates the spontaneous locomotion of rats, although the motor performance of adult rats had not been altered. Nonetheless, they revealed significant tissue impairment in the motor cortex. Additionally, there was a meaningful alteration in both the volume and microarchitecture of alveolar bone in this group. Our results indicate that the model of comorbidity between ligature-induced experimental periodontitis and focal ischemia was capable of inducing greater neurological impairment and alveolar bone loss in rats, attributable to diminished bone quality, when compared to each condition individually. |
| format | Article |
| id | doaj-art-18186381e7b146bb906d30f89d8100ff |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-18186381e7b146bb906d30f89d8100ff2025-02-05T04:32:15ZengElsevierHeliyon2405-84402025-02-01113e42158Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitisVictória dos Santos Chemelo0Marco Aurelio M. Freire1Leonardo Oliveira Bittencourt2Deborah Ribeiro Frazão3Deiweson Souza-Monteiro4Sabrina C. Cartagenes5Walace Gomes-Leal6Cristiane do Socorro Ferraz Maia7Gabriel S. Rocha8Daniel Falcao9Rafael Rodrigues Lima10Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belem, 66075-110, PA, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belem, 66075-110, PA, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belem, 66075-110, PA, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belem, 66075-110, PA, BrazilLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belem, 66075-110, PA, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Pará, Belém, 66075-110, PA, BrazilLaboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Collective Health, Federal University of Western Pará, Santarém, 68040-470, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Pará, Belém, 66075-110, PA, BrazilBehavioral and Evolutionary Neurobiology Laboratory, Department of Biosciences, Federal University of Sergipe, Itabaiana, 49506-036, SE, BrazilVCU Health Systems, Virginia Commonwealth University, Richmond, 23284, VA, USALaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belem, 66075-110, PA, Brazil; Corresponding author.Stroke is a severe medical condition resulting from an interruption in the blood supply to the brain, ultimately compromising tissue homeostasis. Currently, stroke stands as the second leading cause of death worldwide and the third leading cause when considering both mortality and disability together. Periodontitis is characterized by persistent inflammation in hard and soft tissues which support the teeth, primarily caused by bacterial biofilms, and is one of the most common causes of tooth loss in adults and can contribute to a systemic inflammatory burden. In the light of this, the present study investigated the effects of inducing focal ischemia in the motor cortex in rats undergoing experimental periodontitis. Adult Wistar rats were divided into four groups (control, ischemia, periodontitis, and periodontitis + ischemia) and were evaluated for motor performance, basic histology, and the volume and microarchitecture of alveolar bone. The results showed that the comorbidity between ischemia and periodontitis aggravates the spontaneous locomotion of rats, although the motor performance of adult rats had not been altered. Nonetheless, they revealed significant tissue impairment in the motor cortex. Additionally, there was a meaningful alteration in both the volume and microarchitecture of alveolar bone in this group. Our results indicate that the model of comorbidity between ligature-induced experimental periodontitis and focal ischemia was capable of inducing greater neurological impairment and alveolar bone loss in rats, attributable to diminished bone quality, when compared to each condition individually.http://www.sciencedirect.com/science/article/pii/S2405844025005389Motor cortexAlveolar boneMotor performancePeriodontitisBehaviorBrain ischemia |
| spellingShingle | Victória dos Santos Chemelo Marco Aurelio M. Freire Leonardo Oliveira Bittencourt Deborah Ribeiro Frazão Deiweson Souza-Monteiro Sabrina C. Cartagenes Walace Gomes-Leal Cristiane do Socorro Ferraz Maia Gabriel S. Rocha Daniel Falcao Rafael Rodrigues Lima Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis Heliyon Motor cortex Alveolar bone Motor performance Periodontitis Behavior Brain ischemia |
| title | Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis |
| title_full | Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis |
| title_fullStr | Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis |
| title_full_unstemmed | Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis |
| title_short | Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis |
| title_sort | potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis |
| topic | Motor cortex Alveolar bone Motor performance Periodontitis Behavior Brain ischemia |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025005389 |
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