Influence of the NAT2 gene polymorphic markers on the effectiveness and safety of treatment in patients with newly diagnosed pulmonary tuberculosis based on peripheral red blood cell dynamics

Influence of the NAT2 gene polymorphic markers on the effectiveness and safety of treatment in patients with newly diagnosed pulmonary tuberculosis based on peripheral red blood cell dynamics

Background. Individual sensitivity to isoniazid in tuberculosis patients is determined by the presence of N-acetyltransferase 2 (NAT2) enzyme gene allelic variants in genome. Evaluation of quantitative and qualitative alterations in peripheral blood can be used for diagnosis, disease severity estima...

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Main Authors: N. M. Krasnova, S. G. Efremenko, N. E. Evdokimova, O. I. Filippova, Y. V. Chertovskikh, E. A. Alekseeva, O. V. Tatarinova, A. I. Gotovtseva, E. S. Prokopev, A. F. Kravchenko, A. I. Vengerovskiy, D. A. Sychev
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2022-01-01
Series:Антибиотики и Химиотерапия
Subjects:
tuberculosis
isoniazid
n-acetyltransferase 2 (nat2)
acetylation type
erythrocytes
red blood cell index
anemia
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/857
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