Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases
Currently, liver diseases have become a serious global health issue, and this situation occurs due to the exposure of the liver to different agents, such as chemicals, alcohol, viruses, and autoimmune diseases. Mangiferin is a natural bioactive xanthone C-glycoside compound and a potent antioxidant...
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| Format: | Article |
| Language: | English |
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Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
2025-03-01
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| Series: | Journal of Advanced Biotechnology and Experimental Therapeutics |
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| Online Access: | https://www.bsmiab.org/jabet/?mno=233800 |
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| author | Tanvir Zaman Shoyshob Sumaya Akter Muhammad Ramiz Uddin Mithila Farjana Akhi Moni Wonhyo Seo Md. Golzar Hossain Md Jamal Uddin |
| author_facet | Tanvir Zaman Shoyshob Sumaya Akter Muhammad Ramiz Uddin Mithila Farjana Akhi Moni Wonhyo Seo Md. Golzar Hossain Md Jamal Uddin |
| author_sort | Tanvir Zaman Shoyshob |
| collection | DOAJ |
| description | Currently, liver diseases have become a serious global health issue, and this situation occurs due to the exposure of the liver to different agents, such as chemicals, alcohol, viruses, and autoimmune diseases. Mangiferin is a natural bioactive xanthone C-glycoside compound and a potent antioxidant that is widely found in medicinal plants such as the leaves of Mangifera indica L. (Anacardiaceae). It possesses a wide range of biological properties, such as antidiabetic, hepatoprotective, anti-inflammatory, antioxidant, and anticarcinogenic activities. The purpose of this literature review was to delineate the hepatoprotective effects of mangiferin, a natural bioactive compound without side effects, and explain how it protects the liver via the suppression of pathological conditions involved in liver diseases. Relevant published research articles from peer-reviewed journals were searched in PubMed and Google Scholar to gain insights into the consequences of mangiferin in liver diseases. Several studies have suggested that pretreatment with mangiferin decreases hepatic inflammation, oxidative stress, apoptosis, fibrosis, endoplasmic reticulum (ER) stress, and hepatic dysfunction and concomitantly ameliorates the morphological structures of the liver. Therefore, mangiferin could be considered a multitarget therapeutic and promising drug candidate for the treatment of hepatic diseases, although a detailed mechanistic explanation needs to be provided. This literature review highlights the pathological conditions (inflammation, oxidative stress, apoptosis, ER stress) associated with liver diseases as well as the hepatoprotective and therapeutic effects of mangiferin in the liver. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 125-138] |
| format | Article |
| id | doaj-art-1800d2ca40e345948a4488dc5c4361c0 |
| institution | Kabale University |
| issn | 2616-4760 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology |
| record_format | Article |
| series | Journal of Advanced Biotechnology and Experimental Therapeutics |
| spelling | doaj-art-1800d2ca40e345948a4488dc5c4361c02025-01-30T13:01:08ZengBangladesh Society for Microbiology, Immunology, and Advanced BiotechnologyJournal of Advanced Biotechnology and Experimental Therapeutics2616-47602025-03-018112513810.5455/jabet.2025.11233800Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseasesTanvir Zaman Shoyshob0Sumaya Akter1Muhammad Ramiz Uddin2Mithila Farjana3Akhi Moni4Wonhyo Seo5Md. Golzar Hossain6Md Jamal Uddin7ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of KoreaCurrently, liver diseases have become a serious global health issue, and this situation occurs due to the exposure of the liver to different agents, such as chemicals, alcohol, viruses, and autoimmune diseases. Mangiferin is a natural bioactive xanthone C-glycoside compound and a potent antioxidant that is widely found in medicinal plants such as the leaves of Mangifera indica L. (Anacardiaceae). It possesses a wide range of biological properties, such as antidiabetic, hepatoprotective, anti-inflammatory, antioxidant, and anticarcinogenic activities. The purpose of this literature review was to delineate the hepatoprotective effects of mangiferin, a natural bioactive compound without side effects, and explain how it protects the liver via the suppression of pathological conditions involved in liver diseases. Relevant published research articles from peer-reviewed journals were searched in PubMed and Google Scholar to gain insights into the consequences of mangiferin in liver diseases. Several studies have suggested that pretreatment with mangiferin decreases hepatic inflammation, oxidative stress, apoptosis, fibrosis, endoplasmic reticulum (ER) stress, and hepatic dysfunction and concomitantly ameliorates the morphological structures of the liver. Therefore, mangiferin could be considered a multitarget therapeutic and promising drug candidate for the treatment of hepatic diseases, although a detailed mechanistic explanation needs to be provided. This literature review highlights the pathological conditions (inflammation, oxidative stress, apoptosis, ER stress) associated with liver diseases as well as the hepatoprotective and therapeutic effects of mangiferin in the liver. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 125-138]https://www.bsmiab.org/jabet/?mno=233800mangiferin; liver disease; endoplasmic reticulum stress; inflammation; oxidative stress; apoptosis |
| spellingShingle | Tanvir Zaman Shoyshob Sumaya Akter Muhammad Ramiz Uddin Mithila Farjana Akhi Moni Wonhyo Seo Md. Golzar Hossain Md Jamal Uddin Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases Journal of Advanced Biotechnology and Experimental Therapeutics mangiferin; liver disease; endoplasmic reticulum stress; inflammation; oxidative stress; apoptosis |
| title | Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases |
| title_full | Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases |
| title_fullStr | Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases |
| title_full_unstemmed | Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases |
| title_short | Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases |
| title_sort | pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases |
| topic | mangiferin; liver disease; endoplasmic reticulum stress; inflammation; oxidative stress; apoptosis |
| url | https://www.bsmiab.org/jabet/?mno=233800 |
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