Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study
ObjectivesTo identify radiomic features extracted from ultrasound images and to develop and externally validate a comprehensive model that combines clinical data with ultrasound radiomics features to predict the residual tumor status in patients with advanced epithelial ovarian cancer (OC).MethodsTh...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1540734/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542357004746752 |
|---|---|
| author | Shanshan Li Qiuping Ding Lijuan Li Yuwei Liu Hanyu Zou Yushuang Wang Xiangyu Wang Bingqing Deng Qingxiu Ai |
| author_facet | Shanshan Li Qiuping Ding Lijuan Li Yuwei Liu Hanyu Zou Yushuang Wang Xiangyu Wang Bingqing Deng Qingxiu Ai |
| author_sort | Shanshan Li |
| collection | DOAJ |
| description | ObjectivesTo identify radiomic features extracted from ultrasound images and to develop and externally validate a comprehensive model that combines clinical data with ultrasound radiomics features to predict the residual tumor status in patients with advanced epithelial ovarian cancer (OC).MethodsThe study included 112 patients with advanced epithelial OC who underwent preoperative transvaginal ultrasound. Of these, 78 patients were assigned to the development cohort and 34 to the external validation cohort. Tumor contours were manually delineated as regions of interest (ROI) on the ultrasound images, and radiomic features were extracted. The final set of variables was identified using LASSO (least absolute shrinkage and selection operator) regression. Clinical features were also collected and incorporated into the model. A combination model integrating ultrasound radiomics and clinical variables was developed and externally validated. The performance of the predictive models was assessed.ResultsA total of 1,561 radiomic features and 18 clinical features were extracted. The final model included 10 significant ultrasound radiomic variables and 4 clinical features. The comprehensive model outperformed models based on either clinical or radiomic features alone, achieving an accuracy of 0.84, a sensitivity of 0.80, a specificity of 0.75, a precision of 0.88, a positive predictive value of 0.81, a negative predictive value of 0.86, an F1-score of 0.78, and an AUC of 0.82 in the external validation set.ConclusionsThe comprehensive model, which integrated clinical and ultrasound radiomic features, exhibited strong performance and generalizability in preoperatively identifying patients likely to achieve complete resection of all visible disease. |
| format | Article |
| id | doaj-art-17ff7d9b26174686ab5a97d286fd3f27 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-17ff7d9b26174686ab5a97d286fd3f272025-02-04T05:28:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15407341540734Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective studyShanshan Li0Qiuping Ding1Lijuan Li2Yuwei Liu3Hanyu Zou4Yushuang Wang5Xiangyu Wang6Bingqing Deng7Qingxiu Ai8Department of Medical Ultrasound, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, ChinaReproductive Medicine Center, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Enshi, Hubei, ChinaDepartment of Medical Ultrasound, The Ethnic Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, ChinaDepartment of Medical Ultrasound, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, ChinaDepartment of Medical Ultrasound, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, ChinaDepartment of Medical Ultrasound, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, ChinaDepartment of Medical Ultrasound, The Maternal and Child Health and Family Planning Service Center of Enshi Tujia and Miao Autonomous Prefecture, En Shi, Hubei, ChinaDepartment of Medical Ultrasound, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, ChinaDepartment of Medical Ultrasound, The Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, ChinaObjectivesTo identify radiomic features extracted from ultrasound images and to develop and externally validate a comprehensive model that combines clinical data with ultrasound radiomics features to predict the residual tumor status in patients with advanced epithelial ovarian cancer (OC).MethodsThe study included 112 patients with advanced epithelial OC who underwent preoperative transvaginal ultrasound. Of these, 78 patients were assigned to the development cohort and 34 to the external validation cohort. Tumor contours were manually delineated as regions of interest (ROI) on the ultrasound images, and radiomic features were extracted. The final set of variables was identified using LASSO (least absolute shrinkage and selection operator) regression. Clinical features were also collected and incorporated into the model. A combination model integrating ultrasound radiomics and clinical variables was developed and externally validated. The performance of the predictive models was assessed.ResultsA total of 1,561 radiomic features and 18 clinical features were extracted. The final model included 10 significant ultrasound radiomic variables and 4 clinical features. The comprehensive model outperformed models based on either clinical or radiomic features alone, achieving an accuracy of 0.84, a sensitivity of 0.80, a specificity of 0.75, a precision of 0.88, a positive predictive value of 0.81, a negative predictive value of 0.86, an F1-score of 0.78, and an AUC of 0.82 in the external validation set.ConclusionsThe comprehensive model, which integrated clinical and ultrasound radiomic features, exhibited strong performance and generalizability in preoperatively identifying patients likely to achieve complete resection of all visible disease.https://www.frontiersin.org/articles/10.3389/fonc.2025.1540734/fullultrasonic radiomicsovarian cancerpredictive modelnomogramsresidual tumor |
| spellingShingle | Shanshan Li Qiuping Ding Lijuan Li Yuwei Liu Hanyu Zou Yushuang Wang Xiangyu Wang Bingqing Deng Qingxiu Ai Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study Frontiers in Oncology ultrasonic radiomics ovarian cancer predictive model nomograms residual tumor |
| title | Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study |
| title_full | Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study |
| title_fullStr | Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study |
| title_full_unstemmed | Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study |
| title_short | Ultrasonic radiomics-based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer: a multicenter retrospective study |
| title_sort | ultrasonic radiomics based nomogram for preoperative prediction of residual tumor in advanced epithelial ovarian cancer a multicenter retrospective study |
| topic | ultrasonic radiomics ovarian cancer predictive model nomograms residual tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1540734/full |
| work_keys_str_mv | AT shanshanli ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT qiupingding ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT lijuanli ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT yuweiliu ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT hanyuzou ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT yushuangwang ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT xiangyuwang ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT bingqingdeng ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy AT qingxiuai ultrasonicradiomicsbasednomogramforpreoperativepredictionofresidualtumorinadvancedepithelialovariancanceramulticenterretrospectivestudy |