Contribution of Gut Bacteria to Liver Pathobiology
Emerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply from the intestinal venous outflow, the liver repres...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/453563 |
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| _version_ | 1832567077132566528 |
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| author | Gakuhei Son Michael Kremer Ian N. Hines |
| author_facet | Gakuhei Son Michael Kremer Ian N. Hines |
| author_sort | Gakuhei Son |
| collection | DOAJ |
| description | Emerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply from the intestinal venous outflow, the liver represents the first line of defense against gut-derived antigens and is equipped with a broad array of immune cells (i.e., macrophages, lymphocytes, natural killer cells, and dendritic cells) to accomplish this function. In the setting of tissue injury, whereby the liver is otherwise damaged (e.g., viral infection, toxin exposure, ischemic tissue damage, etc.), these same immune cell populations and their interactions with the infiltrating gut bacteria likely contribute to and promote these pathologies. The following paper will highlight recent studies investigating the relationship between the gut microbiota, liver biology, and pathobiology. Defining these connections will likely provide new targets for therapy or prevention of a wide variety of acute and chronic liver pathologies. |
| format | Article |
| id | doaj-art-17fb1d69e0444ac48611ef146274e8f1 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-17fb1d69e0444ac48611ef146274e8f12025-02-03T01:02:25ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/453563453563Contribution of Gut Bacteria to Liver PathobiologyGakuhei Son0Michael Kremer1Ian N. Hines2Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USADepartment of Surgery, University of Heidelberg, 69120, Heidelberg, GermanyDivision of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USAEmerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply from the intestinal venous outflow, the liver represents the first line of defense against gut-derived antigens and is equipped with a broad array of immune cells (i.e., macrophages, lymphocytes, natural killer cells, and dendritic cells) to accomplish this function. In the setting of tissue injury, whereby the liver is otherwise damaged (e.g., viral infection, toxin exposure, ischemic tissue damage, etc.), these same immune cell populations and their interactions with the infiltrating gut bacteria likely contribute to and promote these pathologies. The following paper will highlight recent studies investigating the relationship between the gut microbiota, liver biology, and pathobiology. Defining these connections will likely provide new targets for therapy or prevention of a wide variety of acute and chronic liver pathologies.http://dx.doi.org/10.1155/2010/453563 |
| spellingShingle | Gakuhei Son Michael Kremer Ian N. Hines Contribution of Gut Bacteria to Liver Pathobiology Gastroenterology Research and Practice |
| title | Contribution of Gut Bacteria to Liver Pathobiology |
| title_full | Contribution of Gut Bacteria to Liver Pathobiology |
| title_fullStr | Contribution of Gut Bacteria to Liver Pathobiology |
| title_full_unstemmed | Contribution of Gut Bacteria to Liver Pathobiology |
| title_short | Contribution of Gut Bacteria to Liver Pathobiology |
| title_sort | contribution of gut bacteria to liver pathobiology |
| url | http://dx.doi.org/10.1155/2010/453563 |
| work_keys_str_mv | AT gakuheison contributionofgutbacteriatoliverpathobiology AT michaelkremer contributionofgutbacteriatoliverpathobiology AT iannhines contributionofgutbacteriatoliverpathobiology |