Computational Screening and Experimental Evaluation of Wheat Proteases for Use in the Enzymatic Therapy of Gluten-Related Disorders

Computational Screening and Experimental Evaluation of Wheat Proteases for Use in the Enzymatic Therapy of Gluten-Related Disorders

<b>Background:</b> Gluten-related disorders, particularly celiac disease, are triggered in susceptible individuals by the toxic effects of gluten, the major storage protein of wheat grains. This toxicity can be reduced by wheat glutenases. Members of the papain-like cysteine protease fam...

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Bibliographic Details
Main Authors: Lyudmila V. Savvateeva, Olga E. Chepikova, Alena D. Solonkina, Artemiy A. Sakharov, Neonila V. Gorokhovets, Andrey V. Golovin, Andrey A. Zamyatnin
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
glutenase
gluten
computational screening
celiac disease
Online Access:https://www.mdpi.com/1424-8247/18/4/592
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