Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer
Background. Treatment of patients with a biochemical recurrence (BCR) of prostate cancer (PCa) is generally difficult and without valid treatment options. Since 2004 we have been developing therapeutic possibilities for these patients. Methods. We retrospectively analyzed a cohort of 41 patients wit...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2014/321619 |
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| author | Daniar K. Osmonov Alexey V. Aksenov Annkathrin Boller Almut Kalz Diana Heimann Isa Janssen Klaus-Peter Jünemann |
| author_facet | Daniar K. Osmonov Alexey V. Aksenov Annkathrin Boller Almut Kalz Diana Heimann Isa Janssen Klaus-Peter Jünemann |
| author_sort | Daniar K. Osmonov |
| collection | DOAJ |
| description | Background. Treatment of patients with a biochemical recurrence (BCR) of prostate cancer (PCa) is generally difficult and without valid treatment options. Since 2004 we have been developing therapeutic possibilities for these patients. Methods. We retrospectively analyzed a cohort of 41 patients with a BCR of PCa and a mean followup of 40.3±20.8 months. Group 1 (n=10): salvage radical prostatectomy (sRP) with SePLND (salvage extended pelvic lymph nodes dissection) (initial treatment: combined brachytherapy). Group 2 (n=22): SePLND (initial treatment: radical prostatectomy (RP)). Group 3 (n=9): SePLND (initial treatment: RP and adjuvant radiation therapy (RT)). We observed PSA, PSA-velocity, localization of LNs and LNs+, BCR-free period, and BR (biochemical response). Results. Group 1: 60% with BCR-freedom (mean 27.2 months). Group 2: 63.6% with BCR-freedom (mean 17.5 months). Group 3: 33.3% with BCR-freedom (mean 17.6 months). In total, BCR-freedom was observed in 23 of 41 patients (56.1%) after salvage surgery. 75.6% of all patients showed a BR. 765 LNs were removed and 14.8% of these were LN+. Conclusions. The BCR-free period and BR are comparable in all three groups. Sensibility to ADT can be reestablished and prolonged as a result of SePLND. Multicenter studies are needed for a reliable output. |
| format | Article |
| id | doaj-art-17f43047e3c04435a34b002eafd43346 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-17f43047e3c04435a34b002eafd433462025-02-03T06:11:34ZengWileyAdvances in Urology1687-63691687-63772014-01-01201410.1155/2014/321619321619Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate CancerDaniar K. Osmonov0Alexey V. Aksenov1Annkathrin Boller2Almut Kalz3Diana Heimann4Isa Janssen5Klaus-Peter Jünemann6Department of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyDepartment of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyDepartment of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyDepartment of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyDepartment of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyDepartment of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyDepartment of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straβe 7, 24105 Kiel, GermanyBackground. Treatment of patients with a biochemical recurrence (BCR) of prostate cancer (PCa) is generally difficult and without valid treatment options. Since 2004 we have been developing therapeutic possibilities for these patients. Methods. We retrospectively analyzed a cohort of 41 patients with a BCR of PCa and a mean followup of 40.3±20.8 months. Group 1 (n=10): salvage radical prostatectomy (sRP) with SePLND (salvage extended pelvic lymph nodes dissection) (initial treatment: combined brachytherapy). Group 2 (n=22): SePLND (initial treatment: radical prostatectomy (RP)). Group 3 (n=9): SePLND (initial treatment: RP and adjuvant radiation therapy (RT)). We observed PSA, PSA-velocity, localization of LNs and LNs+, BCR-free period, and BR (biochemical response). Results. Group 1: 60% with BCR-freedom (mean 27.2 months). Group 2: 63.6% with BCR-freedom (mean 17.5 months). Group 3: 33.3% with BCR-freedom (mean 17.6 months). In total, BCR-freedom was observed in 23 of 41 patients (56.1%) after salvage surgery. 75.6% of all patients showed a BR. 765 LNs were removed and 14.8% of these were LN+. Conclusions. The BCR-free period and BR are comparable in all three groups. Sensibility to ADT can be reestablished and prolonged as a result of SePLND. Multicenter studies are needed for a reliable output.http://dx.doi.org/10.1155/2014/321619 |
| spellingShingle | Daniar K. Osmonov Alexey V. Aksenov Annkathrin Boller Almut Kalz Diana Heimann Isa Janssen Klaus-Peter Jünemann Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer Advances in Urology |
| title | Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer |
| title_full | Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer |
| title_fullStr | Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer |
| title_full_unstemmed | Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer |
| title_short | Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer |
| title_sort | extended salvage pelvic lymph node dissection in patients with recurrent prostate cancer |
| url | http://dx.doi.org/10.1155/2014/321619 |
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