Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis
The role of platelet-to-lymphocyte ratio (PLR) in the prognosis of hepatocellular carcinoma (HCC) patients with different Barcelona Clinic Liver Cancer (BCLC) stages remains controversial. This systematic review and meta-analysis aimed to determine the efficacy of PLR on HCC prognosis. Five electron...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/5670949 |
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| author | Wan-fu Lin Mao-feng Zhong Yu-ren Zhang Huan Wang He-tong Zhao Bin-bin Cheng Chang-quan Ling |
| author_facet | Wan-fu Lin Mao-feng Zhong Yu-ren Zhang Huan Wang He-tong Zhao Bin-bin Cheng Chang-quan Ling |
| author_sort | Wan-fu Lin |
| collection | DOAJ |
| description | The role of platelet-to-lymphocyte ratio (PLR) in the prognosis of hepatocellular carcinoma (HCC) patients with different Barcelona Clinic Liver Cancer (BCLC) stages remains controversial. This systematic review and meta-analysis aimed to determine the efficacy of PLR on HCC prognosis. Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC. A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients were finally enrolled to evaluate the association between the pretreatment PLR and clinical outcomes of overall survival (OS), disease-free survival (DFS), and event occurrence in patients with HCC in different BCLC stages. An elevated pretreatment PLR indicated unfavorable worse OS (HR = 1.73; 95% CI: (1.46, 2.04); P<0.00001) and DFS (HR = 1.30; 95% CI: (1.06, 1.60); P=0.01). Subgroup analysis indicated that high PLR indicated poor OS among BCLC-B/C patients without heterogeneity, while PLR in BCLC-A patients indicated high statistical heterogeneity with I2 value of 78%. As for the correlation between PLR and event occurrence, high PLR was related to poor clinical event occurrence only among BCLC-C patients, though obvious heterogeneity was observed in all different BCLC stages. In conclusion, PLR may be a significant biomarker in the prognosis of HCC in different BCLC stages. |
| format | Article |
| id | doaj-art-17ece8e4719b477a839646324a314513 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-17ece8e4719b477a839646324a3145132025-02-03T07:24:21ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/56709495670949Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-AnalysisWan-fu Lin0Mao-feng Zhong1Yu-ren Zhang2Huan Wang3He-tong Zhao4Bin-bin Cheng5Chang-quan Ling6Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaGraduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, ChinaThe role of platelet-to-lymphocyte ratio (PLR) in the prognosis of hepatocellular carcinoma (HCC) patients with different Barcelona Clinic Liver Cancer (BCLC) stages remains controversial. This systematic review and meta-analysis aimed to determine the efficacy of PLR on HCC prognosis. Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC. A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients were finally enrolled to evaluate the association between the pretreatment PLR and clinical outcomes of overall survival (OS), disease-free survival (DFS), and event occurrence in patients with HCC in different BCLC stages. An elevated pretreatment PLR indicated unfavorable worse OS (HR = 1.73; 95% CI: (1.46, 2.04); P<0.00001) and DFS (HR = 1.30; 95% CI: (1.06, 1.60); P=0.01). Subgroup analysis indicated that high PLR indicated poor OS among BCLC-B/C patients without heterogeneity, while PLR in BCLC-A patients indicated high statistical heterogeneity with I2 value of 78%. As for the correlation between PLR and event occurrence, high PLR was related to poor clinical event occurrence only among BCLC-C patients, though obvious heterogeneity was observed in all different BCLC stages. In conclusion, PLR may be a significant biomarker in the prognosis of HCC in different BCLC stages.http://dx.doi.org/10.1155/2018/5670949 |
| spellingShingle | Wan-fu Lin Mao-feng Zhong Yu-ren Zhang Huan Wang He-tong Zhao Bin-bin Cheng Chang-quan Ling Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis |
| title_full | Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis |
| title_fullStr | Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis |
| title_short | Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis |
| title_sort | prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma with different bclc stages a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2018/5670949 |
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