Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh
Background: Cervical cancer poses a significant public health challenge, emphasizing the need for effective screening strategies for early detection. Conventional Pap smear (CPS) has been the standard screening tool for decades, while liquid-based cytology (LBC) was developed to overcome its limitat...
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| Format: | Article |
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Manipal College of Medical Sciences, Pokhara
2025-02-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4386 |
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| author | Shambhavi Suresh Kumar Sutrakar Lokesh Tripathi Parul Singh Rajpoot Priyanka Agrawal Uday Raj Singh Jagannath Jatav Deepti Tiwari Pushpkunjika Sharma |
| author_facet | Shambhavi Suresh Kumar Sutrakar Lokesh Tripathi Parul Singh Rajpoot Priyanka Agrawal Uday Raj Singh Jagannath Jatav Deepti Tiwari Pushpkunjika Sharma |
| author_sort | Shambhavi |
| collection | DOAJ |
| description | Background: Cervical cancer poses a significant public health challenge, emphasizing the need for effective screening strategies for early detection. Conventional Pap smear (CPS) has been the standard screening tool for decades, while liquid-based cytology (LBC) was developed to overcome its limitations. This study compares the efficacy of CPS and LBC in detecting cervical neoplastic lesions.
Aims and Objectives: To determine and compare the efficacy of CPS and LBC as screening tools for early detection of cervical neoplastic lesions in a tertiary care setting.
Materials and Methods: A prospective observational study was conducted on 240 women aged 18 years and above from August 2022 to August 2023. CPS, LBC (Ezyprep™), and colposcopy-guided biopsies were utilized, with histopathology as the gold standard. Statistical analysis involved sensitivity, specificity, and receiver operating characteristic curves.
Results: CPS showed a sensitivity of 59.62%, specificity of 94.19%, and sample adequacy of 93.3%, while LBC exhibited higher sensitivity (89.09%), comparable specificity (91.43%), and better sample adequacy (95.8%). The area under the curve for LBC (0.908) was significantly higher than CPS (0.735). LBC identified more true positives (49 vs. 31) and fewer false negatives (6 vs. 21).
Conclusion: LBC demonstrated superior sensitivity, sample adequacy, and diagnostic accuracy, making it the recommended screening tool for high-risk populations. |
| format | Article |
| id | doaj-art-17c49abb9c5540dc993ca3d76547feb6 |
| institution | Kabale University |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-17c49abb9c5540dc993ca3d76547feb62025-02-01T12:20:51ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-02-011629096https://doi.org/10.71152/ajms.v16i2.4386Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya PradeshShambhavi 0https://orcid.org/0000-0002-0317-0991Suresh Kumar Sutrakar 1https://orcid.org/0000-0002-1892-2770Lokesh Tripathi 2https://orcid.org/0000-0002-3674-0751Parul Singh Rajpoot 3https://orcid.org/0009-0009-1054-0143Priyanka Agrawal 4https://orcid.org/0000-0003-1114-001XUday Raj Singh 5https://orcid.org/0000-0003-0551-2024Jagannath Jatav 6https://orcid.org/0000-0003-1341-7211Deepti Tiwari 7https://orcid.org/0009-0007-1903-0372Pushpkunjika Sharma 8https://orcid.org/0009-0000-7234-9728Junior Resident, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Professor and Head, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Associate Professor, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Junior Resident, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Professor, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Professor, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Associate Professor, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Junior Resident, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Junior Resident, Department of Pathology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Background: Cervical cancer poses a significant public health challenge, emphasizing the need for effective screening strategies for early detection. Conventional Pap smear (CPS) has been the standard screening tool for decades, while liquid-based cytology (LBC) was developed to overcome its limitations. This study compares the efficacy of CPS and LBC in detecting cervical neoplastic lesions. Aims and Objectives: To determine and compare the efficacy of CPS and LBC as screening tools for early detection of cervical neoplastic lesions in a tertiary care setting. Materials and Methods: A prospective observational study was conducted on 240 women aged 18 years and above from August 2022 to August 2023. CPS, LBC (Ezyprep™), and colposcopy-guided biopsies were utilized, with histopathology as the gold standard. Statistical analysis involved sensitivity, specificity, and receiver operating characteristic curves. Results: CPS showed a sensitivity of 59.62%, specificity of 94.19%, and sample adequacy of 93.3%, while LBC exhibited higher sensitivity (89.09%), comparable specificity (91.43%), and better sample adequacy (95.8%). The area under the curve for LBC (0.908) was significantly higher than CPS (0.735). LBC identified more true positives (49 vs. 31) and fewer false negatives (6 vs. 21). Conclusion: LBC demonstrated superior sensitivity, sample adequacy, and diagnostic accuracy, making it the recommended screening tool for high-risk populations.https://ajmsjournal.info/index.php/AJMS/article/view/4386cervical cancer; liquid-based cytology; pap smear; screening accuracy |
| spellingShingle | Shambhavi Suresh Kumar Sutrakar Lokesh Tripathi Parul Singh Rajpoot Priyanka Agrawal Uday Raj Singh Jagannath Jatav Deepti Tiwari Pushpkunjika Sharma Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh Asian Journal of Medical Sciences cervical cancer; liquid-based cytology; pap smear; screening accuracy |
| title | Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh |
| title_full | Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh |
| title_fullStr | Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh |
| title_full_unstemmed | Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh |
| title_short | Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madhya Pradesh |
| title_sort | comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural madhya pradesh |
| topic | cervical cancer; liquid-based cytology; pap smear; screening accuracy |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4386 |
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