Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario
Before the introduction of the conjugate vaccine, Haemophilus influenzae serotype b (Hib) was the leading cause of bacterial meningitis in children. Although successful in reducing Hib cases, the vaccine confers no protection against other serotypes of H influenzae, such as a (Hia), or f (Hif). The...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2013/828730 |
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| author | Pouya Sadeghi-Aval Raymond SW Tsang Frances B Jamieson Marina Ulanova |
| author_facet | Pouya Sadeghi-Aval Raymond SW Tsang Frances B Jamieson Marina Ulanova |
| author_sort | Pouya Sadeghi-Aval |
| collection | DOAJ |
| description | Before the introduction of the conjugate vaccine, Haemophilus influenzae serotype b (Hib) was the leading cause of bacterial meningitis in children. Although successful in reducing Hib cases, the vaccine confers no protection against other serotypes of H influenzae, such as a (Hia), or f (Hif). The emergence of invasive disease caused by non-Hib in northwestern Ontario (38 cases between 2002 and 2008) with predominance of Hia was previously reported by the authors. At that time, no cases of pediatric meningitis caused by H influenzae were recorded in the region. Continued surveillance identified 12 new cases of invasive non-Hib between January 2009 and July 2011. Among these cases, three young children developed meningitis with severe complications caused by Hia or Hif. The present article describes these cases along with the characteristics of recent H influenzae isolates from the region, (ie, their genetic background and antibiotic sensitivity). The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasive H influenzae infections in northwestern Ontario. |
| format | Article |
| id | doaj-art-17bb40af60c242ea8cb7f8486a75d782 |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-17bb40af60c242ea8cb7f8486a75d7822025-02-03T06:45:56ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322013-01-01241131610.1155/2013/828730Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern OntarioPouya Sadeghi-Aval0Raymond SW Tsang1Frances B Jamieson2Marina Ulanova3Northern Ontario School of Medicine, Thunder Bay, Ontario, CanadaVaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, CanadaPublic Health Laboratories, Public Health Ontario, CanadaNorthern Ontario School of Medicine, Thunder Bay, Ontario, CanadaBefore the introduction of the conjugate vaccine, Haemophilus influenzae serotype b (Hib) was the leading cause of bacterial meningitis in children. Although successful in reducing Hib cases, the vaccine confers no protection against other serotypes of H influenzae, such as a (Hia), or f (Hif). The emergence of invasive disease caused by non-Hib in northwestern Ontario (38 cases between 2002 and 2008) with predominance of Hia was previously reported by the authors. At that time, no cases of pediatric meningitis caused by H influenzae were recorded in the region. Continued surveillance identified 12 new cases of invasive non-Hib between January 2009 and July 2011. Among these cases, three young children developed meningitis with severe complications caused by Hia or Hif. The present article describes these cases along with the characteristics of recent H influenzae isolates from the region, (ie, their genetic background and antibiotic sensitivity). The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasive H influenzae infections in northwestern Ontario.http://dx.doi.org/10.1155/2013/828730 |
| spellingShingle | Pouya Sadeghi-Aval Raymond SW Tsang Frances B Jamieson Marina Ulanova Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario |
| title_full | Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario |
| title_fullStr | Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario |
| title_full_unstemmed | Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario |
| title_short | Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario |
| title_sort | emergence of non serotype b encapsulated haemophilus influenzae as a cause of pediatric meningitis in northwestern ontario |
| url | http://dx.doi.org/10.1155/2013/828730 |
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