Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking
Recently, the global epidemic of obesity is increasing significantly. Obesity is treated with anti-obesity medications and surgery and complications related to these treatments prompt the search of phytochemicals that confer anti-obesity effects. Artemisiae Argyi Folium (Aiye), a Chinese herb used a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | International Journal of Food Properties |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2025.2452445 |
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| Summary: | Recently, the global epidemic of obesity is increasing significantly. Obesity is treated with anti-obesity medications and surgery and complications related to these treatments prompt the search of phytochemicals that confer anti-obesity effects. Artemisiae Argyi Folium (Aiye), a Chinese herb used as both food and medicine, exhibits potent anti-obesity effects. Aiye essential oil components are responsible for lipase activity inhibition, intestinal barrier protection, and blood lipid regulation effects. The current research aims to identify the anti-obesity essential oil components of Aiye through the integration of GC-MS, network pharmacology, and molecular docking. In present study, the Aiye essential oil components were identified by GC-MS analysis. Network pharmacology and molecular docking were integrated to predict the anti-obesity mechanisms of Aiye essential oil components. In total, 49 essential oil components were identified, containing 308 anti-obesity targets. The network pharmacology analysis revealed that the essential oil components may combat obesity through the Wnt signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, prolactin signaling pathway, and cAMP signaling pathway, etc. For molecular docking, there were 99 out of 140 with a binding affinity of less than −5 kcal/mol, indicating a moderate binding between essential oil components and targets. The present study revealed 308 potential anti-obesity targets of 49 essential oil components of Aiye. More than 70% of the binding between components and targets had moderate interaction. More than five anti-obesity signaling pathways of 49 Aiye essential oil components were identified. Therefore, the current research indicated that the essential oil components of Aiye may confer anti-obesity benefits. |
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| ISSN: | 1094-2912 1532-2386 |