Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans
Background/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I (𝑛=22) wa...
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2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/159438 |
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| author | Ilyas Tuncer Mustafa Harman Yasar Colak Ismail Arslan M. Kursad Turkdogan |
| author_facet | Ilyas Tuncer Mustafa Harman Yasar Colak Ismail Arslan M. Kursad Turkdogan |
| author_sort | Ilyas Tuncer |
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| description | Background/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I (𝑛=22) was given UDCA (15 mg/kg/day) alone and group II (𝑛=18) was treated with domperidone (30 mg/day) in addition to UDCA. The control group (𝑛=13) was followed without a medical treatment. Gallbladder volumes and ejection fractions were measured sonographically in all patients before and after treatment. Results. After 12 months of treatment, stone dissolution was found in 9 (40.9%) of the patients in group I and 7 (38.8%) of the patients in group II. The difference was statistically significant compared to controls in both treatment groups (𝑃<0.05) but the two groups did not show a difference between each other (𝑃>0.05). All the patients that achieved dissolution had multiple gallstones except for one patient with a solitary stone in group I. Neither monotherapy of UDCA nor the combination with domperidone affected the ejection fraction of gallbladder. Conclusions. Combination with domperidone did not potentiate the efficacy of UDCA. It has been observed that both UDCA alone and UDCA plus domperidone treatment did not affect ejection fraction of gallbladder. |
| format | Article |
| id | doaj-art-179a5d9cb8f240c2baec02452a3b806f |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-179a5d9cb8f240c2baec02452a3b806f2025-02-03T05:47:58ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/159438159438Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in HumansIlyas Tuncer0Mustafa Harman1Yasar Colak2Ismail Arslan3M. Kursad Turkdogan4Department of Gastroenterology, Istanbul Medeniyet University, Medical Faculty, Goztepe Education and Research Hospital, Istanbul, TurkeyDepartments of Radiology, Yuzuncu Yil University Medical Faculty, Van, TurkeyDepartment of Gastroenterology, Istanbul Medeniyet University, Medical Faculty, Goztepe Education and Research Hospital, Istanbul, TurkeyDepartments of Radiology, Yuzuncu Yil University Medical Faculty, Van, TurkeyDepartment of Gastroenterology, Bezmiâlem Vakif University Medical Faculty, Istanbul, TurkeyBackground/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I (𝑛=22) was given UDCA (15 mg/kg/day) alone and group II (𝑛=18) was treated with domperidone (30 mg/day) in addition to UDCA. The control group (𝑛=13) was followed without a medical treatment. Gallbladder volumes and ejection fractions were measured sonographically in all patients before and after treatment. Results. After 12 months of treatment, stone dissolution was found in 9 (40.9%) of the patients in group I and 7 (38.8%) of the patients in group II. The difference was statistically significant compared to controls in both treatment groups (𝑃<0.05) but the two groups did not show a difference between each other (𝑃>0.05). All the patients that achieved dissolution had multiple gallstones except for one patient with a solitary stone in group I. Neither monotherapy of UDCA nor the combination with domperidone affected the ejection fraction of gallbladder. Conclusions. Combination with domperidone did not potentiate the efficacy of UDCA. It has been observed that both UDCA alone and UDCA plus domperidone treatment did not affect ejection fraction of gallbladder.http://dx.doi.org/10.1155/2012/159438 |
| spellingShingle | Ilyas Tuncer Mustafa Harman Yasar Colak Ismail Arslan M. Kursad Turkdogan Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans Gastroenterology Research and Practice |
| title | Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans |
| title_full | Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans |
| title_fullStr | Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans |
| title_full_unstemmed | Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans |
| title_short | Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans |
| title_sort | effect of ursodeoxycholic acid alone and ursodeoxycholic acid plus domperidone on radiolucent gallstones and gallbladder contractility in humans |
| url | http://dx.doi.org/10.1155/2012/159438 |
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