Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment
Abstract Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these microbiota in the development of gastric cancer remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis,...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06142-w |
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| author | Ping Yang Gaoli Liang Yangyue Ni Xiaojie Chu Xiaoshan Zhang Zhongyu Wang Adeel Khan Fangfang Jin Han Shen Miao Li Zhipeng Xu |
| author_facet | Ping Yang Gaoli Liang Yangyue Ni Xiaojie Chu Xiaoshan Zhang Zhongyu Wang Adeel Khan Fangfang Jin Han Shen Miao Li Zhipeng Xu |
| author_sort | Ping Yang |
| collection | DOAJ |
| description | Abstract Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these microbiota in the development of gastric cancer remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis, we identified enrichment of specific microbial communities within tumors of gastric cancer patients, possibly affecting the tumor microenvironment by immune modulation, metabolic processes, and inflammatory responses. Based on the results of in vivo experiments and intratumoral microbiota analysis, we found that Streptococcus mitis can inhibit gastric cancer progression via suppressing M2 macrophage polarization and infiltration, as well as altering the intratumoral microbial community. In summary, our findings suggest that the intratumoral microbiota, exemplified by Streptococcus mites, may be involved in regulating the progression of gastric cancer, thereby emerging as potential therapeutic targets for this disease. |
| format | Article |
| id | doaj-art-179a026e082a483d8c25e282236326d0 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-179a026e082a483d8c25e282236326d02025-02-02T12:40:34ZengBMCJournal of Translational Medicine1479-58762025-01-0123111110.1186/s12967-025-06142-wInvestigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironmentPing Yang0Gaoli Liang1Yangyue Ni2Xiaojie Chu3Xiaoshan Zhang4Zhongyu Wang5Adeel Khan6Fangfang Jin7Han Shen8Miao Li9Zhipeng Xu10Department of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Physiology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, NJU Advanced Institute of Life Sciences (NAILS), Nanjing UniversityDepartment of Pathogen Biology, Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Nanjing Medical UniversityDepartment of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Physiology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences, NJU Advanced Institute of Life Sciences (NAILS), Nanjing UniversityDepartment of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityDepartment of Biotechnology, University of Science and Technology BannuSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineDepartment of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityDepartment of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityDepartment of Pathogen Biology, Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Nanjing Medical UniversityAbstract Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these microbiota in the development of gastric cancer remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis, we identified enrichment of specific microbial communities within tumors of gastric cancer patients, possibly affecting the tumor microenvironment by immune modulation, metabolic processes, and inflammatory responses. Based on the results of in vivo experiments and intratumoral microbiota analysis, we found that Streptococcus mitis can inhibit gastric cancer progression via suppressing M2 macrophage polarization and infiltration, as well as altering the intratumoral microbial community. In summary, our findings suggest that the intratumoral microbiota, exemplified by Streptococcus mites, may be involved in regulating the progression of gastric cancer, thereby emerging as potential therapeutic targets for this disease.https://doi.org/10.1186/s12967-025-06142-wGastric cancerIntratumoral MicrobiotaStreptococcus mitisTumor microenvironment |
| spellingShingle | Ping Yang Gaoli Liang Yangyue Ni Xiaojie Chu Xiaoshan Zhang Zhongyu Wang Adeel Khan Fangfang Jin Han Shen Miao Li Zhipeng Xu Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment Journal of Translational Medicine Gastric cancer Intratumoral Microbiota Streptococcus mitis Tumor microenvironment |
| title | Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment |
| title_full | Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment |
| title_fullStr | Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment |
| title_full_unstemmed | Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment |
| title_short | Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment |
| title_sort | investigating the role of intratumoral streptococcus mitis in gastric cancer progression insights into tumor microenvironment |
| topic | Gastric cancer Intratumoral Microbiota Streptococcus mitis Tumor microenvironment |
| url | https://doi.org/10.1186/s12967-025-06142-w |
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