Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism
Aortic dissection is a life-threatening condition caused by a tear in the intimal layer of the aorta or bleeding within the aortic wall, resulting in the separation of the layers of the aortic wall. As Nienaber reported, aortic dissection is most common in people 65–75 years old and has an incidence...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2022/2371401 |
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| author | Ruibin Wei Yingqing Feng |
| author_facet | Ruibin Wei Yingqing Feng |
| author_sort | Ruibin Wei |
| collection | DOAJ |
| description | Aortic dissection is a life-threatening condition caused by a tear in the intimal layer of the aorta or bleeding within the aortic wall, resulting in the separation of the layers of the aortic wall. As Nienaber reported, aortic dissection is most common in people 65–75 years old and has an incidence of 35 cases per 100,000 people per year in this population. Many pathogenic factors are involved in aortic dissection, including hypertension, dyslipidemia, and abnormality of the aortic intima caused by genetic variation. However, with the development of gene sequencing and transgenic technology, genetic methods are being used for the diagnosis and treatment of diseases, including acute aortic dissection. Genetic research on acute aortic dissection began around 2006. Recently, research on acute aortic dissection has mainly focused on microRNA (miRNA). Studies have found that miRNA plays a critical regulatory role in the occurrence and development of acute aortic dissection. By regulating miRNA expression, acute aortic dissection can be prevented and treated. |
| format | Article |
| id | doaj-art-1794ca337e634a4b8b69683cb5acc335 |
| institution | Kabale University |
| issn | 1755-5922 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-1794ca337e634a4b8b69683cb5acc3352025-02-03T05:58:31ZengWileyCardiovascular Therapeutics1755-59222022-01-01202210.1155/2022/2371401Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to MechanismRuibin Wei0Yingqing Feng1Department of CardiologyThe Second School of Clinical MedicineAortic dissection is a life-threatening condition caused by a tear in the intimal layer of the aorta or bleeding within the aortic wall, resulting in the separation of the layers of the aortic wall. As Nienaber reported, aortic dissection is most common in people 65–75 years old and has an incidence of 35 cases per 100,000 people per year in this population. Many pathogenic factors are involved in aortic dissection, including hypertension, dyslipidemia, and abnormality of the aortic intima caused by genetic variation. However, with the development of gene sequencing and transgenic technology, genetic methods are being used for the diagnosis and treatment of diseases, including acute aortic dissection. Genetic research on acute aortic dissection began around 2006. Recently, research on acute aortic dissection has mainly focused on microRNA (miRNA). Studies have found that miRNA plays a critical regulatory role in the occurrence and development of acute aortic dissection. By regulating miRNA expression, acute aortic dissection can be prevented and treated.http://dx.doi.org/10.1155/2022/2371401 |
| spellingShingle | Ruibin Wei Yingqing Feng Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism Cardiovascular Therapeutics |
| title | Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism |
| title_full | Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism |
| title_fullStr | Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism |
| title_full_unstemmed | Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism |
| title_short | Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism |
| title_sort | noncoding rna in the regulation of acute aortic dissection from profile to mechanism |
| url | http://dx.doi.org/10.1155/2022/2371401 |
| work_keys_str_mv | AT ruibinwei noncodingrnaintheregulationofacuteaorticdissectionfromprofiletomechanism AT yingqingfeng noncodingrnaintheregulationofacuteaorticdissectionfromprofiletomechanism |