Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome
Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing’s syndrome (ECS). MTC can be hereditary as a pa...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/6414921 |
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| author | Aleksandra I. Pivovarova Stephanie Patrick Punuru J. Reddy |
| author_facet | Aleksandra I. Pivovarova Stephanie Patrick Punuru J. Reddy |
| author_sort | Aleksandra I. Pivovarova |
| collection | DOAJ |
| description | Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing’s syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing’s Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes. |
| format | Article |
| id | doaj-art-1783faff51104246b6a0f6a83b932a87 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-1783faff51104246b6a0f6a83b932a872025-02-03T05:46:30ZengWileyCase Reports in Endocrinology2090-65012090-651X2019-01-01201910.1155/2019/64149216414921Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing SyndromeAleksandra I. Pivovarova0Stephanie Patrick1Punuru J. Reddy2Alabama College of Osteopathic Medicine, 445 Health Sciences Blvd, Dothan, AL 36303, USAAlabama College of Osteopathic Medicine, 445 Health Sciences Blvd, Dothan, AL 36303, USADecatur Morgan Hospital, Department of Internal Medicine, 1201 7th St. SE, Decatur, AL 35601, USAMedullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing’s syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing’s Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes.http://dx.doi.org/10.1155/2019/6414921 |
| spellingShingle | Aleksandra I. Pivovarova Stephanie Patrick Punuru J. Reddy Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome Case Reports in Endocrinology |
| title | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
| title_full | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
| title_fullStr | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
| title_full_unstemmed | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
| title_short | Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome |
| title_sort | sporadic medullary thyroid carcinoma with paraneoplastic cushing syndrome |
| url | http://dx.doi.org/10.1155/2019/6414921 |
| work_keys_str_mv | AT aleksandraipivovarova sporadicmedullarythyroidcarcinomawithparaneoplasticcushingsyndrome AT stephaniepatrick sporadicmedullarythyroidcarcinomawithparaneoplasticcushingsyndrome AT punurujreddy sporadicmedullarythyroidcarcinomawithparaneoplasticcushingsyndrome |