Increased sagittal abdominal diameter is associated with a higher risk of kidney stones.
<h4>Background</h4>This study investigates the relationship between sagittal abdominal diameter (SAD), a measure of abdominal obesity, and kidney stone disease (KSD) in the U.S. population. Additionally, it explores potential underlying mechanisms and evaluates the clinical utility of a...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317717 |
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| _version_ | 1832575441669455872 |
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| author | Wei Song Shugen Li Guangchun Wang Shang Gao |
| author_facet | Wei Song Shugen Li Guangchun Wang Shang Gao |
| author_sort | Wei Song |
| collection | DOAJ |
| description | <h4>Background</h4>This study investigates the relationship between sagittal abdominal diameter (SAD), a measure of abdominal obesity, and kidney stone disease (KSD) in the U.S. population. Additionally, it explores potential underlying mechanisms and evaluates the clinical utility of a predictive model.<h4>Methods</h4>Data were collected from 11,671 participants, including 1,136 cases of KSD. Univariate and multivariate logistic regression analyses, dose-response curves, and mediation effect assessments were employed to examine the association between SAD and KSD. A predictive model was developed and validated using calibration curves, receiver operating characteristic (ROC) curves, and clinical decision curves. Additionally, hematological indicators were analyzed to identify potential mediating factors.<h4>Results</h4>SAD showed a strong and positive association with KSD, even after adjusting for confounders such as gender, age, and education. The predictive model demonstrated moderate accuracy (AUC = 0.661) and clinical utility. Hematological analyses indicated that granulocyte count (GRAN) significantly mediated the relationship between SAD and KSD (P < 0.001).<h4>Conclusions</h4>SAD is a significant risk factor for KSD, underscoring the role of abdominal obesity in kidney stone formation. The predictive model demonstrates potential clinical applications for early risk assessment and management of KSD. |
| format | Article |
| id | doaj-art-177fa59f249a465b85945af431f6f716 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-177fa59f249a465b85945af431f6f7162025-02-01T05:30:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031771710.1371/journal.pone.0317717Increased sagittal abdominal diameter is associated with a higher risk of kidney stones.Wei SongShugen LiGuangchun WangShang Gao<h4>Background</h4>This study investigates the relationship between sagittal abdominal diameter (SAD), a measure of abdominal obesity, and kidney stone disease (KSD) in the U.S. population. Additionally, it explores potential underlying mechanisms and evaluates the clinical utility of a predictive model.<h4>Methods</h4>Data were collected from 11,671 participants, including 1,136 cases of KSD. Univariate and multivariate logistic regression analyses, dose-response curves, and mediation effect assessments were employed to examine the association between SAD and KSD. A predictive model was developed and validated using calibration curves, receiver operating characteristic (ROC) curves, and clinical decision curves. Additionally, hematological indicators were analyzed to identify potential mediating factors.<h4>Results</h4>SAD showed a strong and positive association with KSD, even after adjusting for confounders such as gender, age, and education. The predictive model demonstrated moderate accuracy (AUC = 0.661) and clinical utility. Hematological analyses indicated that granulocyte count (GRAN) significantly mediated the relationship between SAD and KSD (P < 0.001).<h4>Conclusions</h4>SAD is a significant risk factor for KSD, underscoring the role of abdominal obesity in kidney stone formation. The predictive model demonstrates potential clinical applications for early risk assessment and management of KSD.https://doi.org/10.1371/journal.pone.0317717 |
| spellingShingle | Wei Song Shugen Li Guangchun Wang Shang Gao Increased sagittal abdominal diameter is associated with a higher risk of kidney stones. PLoS ONE |
| title | Increased sagittal abdominal diameter is associated with a higher risk of kidney stones. |
| title_full | Increased sagittal abdominal diameter is associated with a higher risk of kidney stones. |
| title_fullStr | Increased sagittal abdominal diameter is associated with a higher risk of kidney stones. |
| title_full_unstemmed | Increased sagittal abdominal diameter is associated with a higher risk of kidney stones. |
| title_short | Increased sagittal abdominal diameter is associated with a higher risk of kidney stones. |
| title_sort | increased sagittal abdominal diameter is associated with a higher risk of kidney stones |
| url | https://doi.org/10.1371/journal.pone.0317717 |
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