Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications
Antimicrobial peptides (AMPs) are activated in response to septic injury and have important roles in vertebrate and invertebrate immune systems. AMPs act directly against pathogens and have both wound healing and antitumor activities. Although coleopterans comprise the largest and most diverse order...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/101989 |
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| author | Monde Ntwasa Akira Goto Shoichiro Kurata |
| author_facet | Monde Ntwasa Akira Goto Shoichiro Kurata |
| author_sort | Monde Ntwasa |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are activated in response to septic injury and have important roles in vertebrate and invertebrate immune systems. AMPs act directly against pathogens and have both wound healing and antitumor activities. Although coleopterans comprise the largest and most diverse order of eukaryotes and occupy an earlier branch than Drosophila in the holometabolous lineage of insects, their immune system has not been studied extensively. Initial research reports, however, indicate that coleopterans possess unique immune response mechanisms, and studies of these novel mechanisms may help to further elucidate innate immunity. Recently, the complete genome sequence of Tribolium was published, boosting research on coleopteran immunity and leading to the identification of Tribolium AMPs that are shared by Drosophila and mammals, as well as other AMPs that are unique. AMPs have potential applicability in the development of vaccines. Here, we review coleopteran AMPs, their potential impact on clinical medicine, and the molecular basis of immune defense. |
| format | Article |
| id | doaj-art-177f28fdf4bf4fd5b7a16d99576626b2 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-177f28fdf4bf4fd5b7a16d99576626b22025-02-03T05:45:50ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/101989101989Coleopteran Antimicrobial Peptides: Prospects for Clinical ApplicationsMonde Ntwasa0Akira Goto1Shoichiro Kurata2School of Molecular and Cell Biology, University of the Witwatersrand, Wits 2050, South AfricaGraduate School of Pharmaceutical Sciences, Tohoku University, Aoba 6-3, Aramaki, Aoba-ku, Sendai 980-8578, JapanGraduate School of Pharmaceutical Sciences, Tohoku University, Aoba 6-3, Aramaki, Aoba-ku, Sendai 980-8578, JapanAntimicrobial peptides (AMPs) are activated in response to septic injury and have important roles in vertebrate and invertebrate immune systems. AMPs act directly against pathogens and have both wound healing and antitumor activities. Although coleopterans comprise the largest and most diverse order of eukaryotes and occupy an earlier branch than Drosophila in the holometabolous lineage of insects, their immune system has not been studied extensively. Initial research reports, however, indicate that coleopterans possess unique immune response mechanisms, and studies of these novel mechanisms may help to further elucidate innate immunity. Recently, the complete genome sequence of Tribolium was published, boosting research on coleopteran immunity and leading to the identification of Tribolium AMPs that are shared by Drosophila and mammals, as well as other AMPs that are unique. AMPs have potential applicability in the development of vaccines. Here, we review coleopteran AMPs, their potential impact on clinical medicine, and the molecular basis of immune defense.http://dx.doi.org/10.1155/2012/101989 |
| spellingShingle | Monde Ntwasa Akira Goto Shoichiro Kurata Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications International Journal of Microbiology |
| title | Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications |
| title_full | Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications |
| title_fullStr | Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications |
| title_full_unstemmed | Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications |
| title_short | Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications |
| title_sort | coleopteran antimicrobial peptides prospects for clinical applications |
| url | http://dx.doi.org/10.1155/2012/101989 |
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