Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy
It was found that in an osteoporotic bone the fraction of nanosized pores decreases, the mineral phase amorphizes, hydrated shells around mineralized particles of the bone matrix thicken, and adhesion forces increase. This contributes to the formation of water clusters similar to bulk water clusters...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/162041 |
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| _version_ | 1832550048102088704 |
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| author | A. A. Gaidash L. N. Sinitsa O. A. Babenko A. A. Lugovskoy |
| author_facet | A. A. Gaidash L. N. Sinitsa O. A. Babenko A. A. Lugovskoy |
| author_sort | A. A. Gaidash |
| collection | DOAJ |
| description | It was found that in an osteoporotic bone the fraction of nanosized pores decreases, the mineral phase amorphizes, hydrated shells around mineralized particles of the bone matrix thicken, and adhesion forces increase. This contributes to the formation of water clusters similar to bulk water clusters compared to the healthy bone tissue and leads to the accumulation of more viscous liquid with increased intermolecular interaction forces in the pores of the bone matrix. Given this, the rates of chemical reactions proceeding in the water phase of ultrathin channels of general parts of collagen fibrils decrease. Ultimately, nanopores of collagen-apatite interfaces lose, to a certain extent, the capability of catalyzing the hydroxyapatite crystallization. |
| format | Article |
| id | doaj-art-177d3e2c11904f5db6cf16fb4613d4d6 |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-177d3e2c11904f5db6cf16fb4613d4d62025-02-03T06:07:49ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/162041162041Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR SpectroscopyA. A. Gaidash0L. N. Sinitsa1O. A. Babenko2A. A. Lugovskoy3Department of Pharmacology, Siberian Federal Medical University, Krasnoyarsk 660041, RussiaLaboratory of Molecular Spectroscopy, V.E. Zuev Institute of Atmospheric Optics SB RAS, Tomsk 634021, RussiaDepartment of Pharmacology, Siberian Federal Medical University, Krasnoyarsk 660041, RussiaLaboratory of Molecular Spectroscopy, V.E. Zuev Institute of Atmospheric Optics SB RAS, Tomsk 634021, RussiaIt was found that in an osteoporotic bone the fraction of nanosized pores decreases, the mineral phase amorphizes, hydrated shells around mineralized particles of the bone matrix thicken, and adhesion forces increase. This contributes to the formation of water clusters similar to bulk water clusters compared to the healthy bone tissue and leads to the accumulation of more viscous liquid with increased intermolecular interaction forces in the pores of the bone matrix. Given this, the rates of chemical reactions proceeding in the water phase of ultrathin channels of general parts of collagen fibrils decrease. Ultimately, nanopores of collagen-apatite interfaces lose, to a certain extent, the capability of catalyzing the hydroxyapatite crystallization.http://dx.doi.org/10.4061/2011/162041 |
| spellingShingle | A. A. Gaidash L. N. Sinitsa O. A. Babenko A. A. Lugovskoy Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy Journal of Osteoporosis |
| title | Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy |
| title_full | Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy |
| title_fullStr | Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy |
| title_full_unstemmed | Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy |
| title_short | Nanoporous Structure of Bone Matrix at Osteoporosis from Data of Atomic Force Microscopy and IR Spectroscopy |
| title_sort | nanoporous structure of bone matrix at osteoporosis from data of atomic force microscopy and ir spectroscopy |
| url | http://dx.doi.org/10.4061/2011/162041 |
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