Nutritional and Pharmacological Enhancement of the Gut-Associated Lymphoid Tissue
There has been an explosion of research in the field of nutrition over the past quarter century. Clinical studies have demonstrated the effectiveness of providing nutrition by the enteral route in reducing septic morbidity in critically ill patients. These improved outcomes have been substantiated b...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/308787 |
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| Summary: | There has been an
explosion of research in the field of nutrition over the past quarter
century. Clinical studies have demonstrated the effectiveness of
providing nutrition by the enteral route in reducing septic morbidity
in critically ill patients. These improved outcomes have been
substantiated by animal models that show that enteral nutrition
decreases gut permeability while maintaining the gut-associated
lymphoid tissue (GALT) in mucosal immunity. Evidence points
to the important immunological role of the gut in the maintenance
of mucosal immunity at both intestinal and extraintestinal
sites. The preservation of this mucosal immunity by enteral nutrition
is consistent with the lower morbidity seen in severely injured
patients who receive nutrition via the gastrointestinal tract. For
patients who are unable to be fed by the enteral route and who require
parenteral nutrition, several supplements show promise in
enhancing the mucosal immune system defenses. The nutritional
and pharmacological tactics that may enhance the GALT and
thereby maintain mucosal immunity are examined. |
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| ISSN: | 0835-7900 |