Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma
Neuroblastoma is a type of cancer that develops most often in infants and children under the age of five years. Neuroblastoma originates within the peripheral sympathetic ganglia, with 30% of the cases developing within the adrenal medulla, although it can also occur within other regions of the body...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/150634 |
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| author | Alfred Buhagiar Duncan Ayers |
| author_facet | Alfred Buhagiar Duncan Ayers |
| author_sort | Alfred Buhagiar |
| collection | DOAJ |
| description | Neuroblastoma is a type of cancer that develops most often in infants and children under the age of five years. Neuroblastoma originates within the peripheral sympathetic ganglia, with 30% of the cases developing within the adrenal medulla, although it can also occur within other regions of the body such as nerve tissue in the spinal cord, neck, chest, abdomen, and pelvis. MicroRNAs (miRNAs) regulate cellular pathways, differentiation, apoptosis, and stem cell maintenance. Such miRNAs regulate genes involved in cellular processes. Consequently, they are implicated in the regulation of a spectrum of signaling pathways within the cell. In essence, the role of miRNAs in the development of cancer is of utmost importance for the understanding of dysfunctional cellular pathways that lead to the conversion of normal cells into cancer cells. This review focuses on highlighting the recent, important implications of miRNAs within the context of neuroblastoma basic research efforts, particularly concerning miRNA influences on cancer stem cell pathology and chemoresistance pathology for this condition, together with development of translational medicine approaches for novel diagnostic tools and therapies for this neuroblastoma. |
| format | Article |
| id | doaj-art-1773d189d358449e9a557893550210b1 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-1773d189d358449e9a557893550210b12025-02-03T06:46:20ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/150634150634Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for NeuroblastomaAlfred Buhagiar0Duncan Ayers1School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol BS8 1TH, UKCentre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, MaltaNeuroblastoma is a type of cancer that develops most often in infants and children under the age of five years. Neuroblastoma originates within the peripheral sympathetic ganglia, with 30% of the cases developing within the adrenal medulla, although it can also occur within other regions of the body such as nerve tissue in the spinal cord, neck, chest, abdomen, and pelvis. MicroRNAs (miRNAs) regulate cellular pathways, differentiation, apoptosis, and stem cell maintenance. Such miRNAs regulate genes involved in cellular processes. Consequently, they are implicated in the regulation of a spectrum of signaling pathways within the cell. In essence, the role of miRNAs in the development of cancer is of utmost importance for the understanding of dysfunctional cellular pathways that lead to the conversion of normal cells into cancer cells. This review focuses on highlighting the recent, important implications of miRNAs within the context of neuroblastoma basic research efforts, particularly concerning miRNA influences on cancer stem cell pathology and chemoresistance pathology for this condition, together with development of translational medicine approaches for novel diagnostic tools and therapies for this neuroblastoma.http://dx.doi.org/10.1155/2015/150634 |
| spellingShingle | Alfred Buhagiar Duncan Ayers Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma Analytical Cellular Pathology |
| title | Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma |
| title_full | Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma |
| title_fullStr | Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma |
| title_full_unstemmed | Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma |
| title_short | Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma |
| title_sort | chemoresistance cancer stem cells and mirna influences the case for neuroblastoma |
| url | http://dx.doi.org/10.1155/2015/150634 |
| work_keys_str_mv | AT alfredbuhagiar chemoresistancecancerstemcellsandmirnainfluencesthecaseforneuroblastoma AT duncanayers chemoresistancecancerstemcellsandmirnainfluencesthecaseforneuroblastoma |